2014年10月30日 · Infiltrating lobular breast cancer (ILBC) is a special breast cancer subtype, which accounts for 10–15% of all mammary carcinomas and for ∼1% of all malignancies. Here, we report on a high frequency of lobular breast cancer in patients with orbital metastases identified in an original series of metastatic tumor specimens and by a systematic ...

Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular, invasive cribriform, mucinous, and invasive micropapillary carcinomas.

2014年10月1日 · Here, we report on a high frequency of lobular breast cancer in patients with orbital metastases identified in an original series of metastatic tumor specimens and by a systematic literature...

Metastasis to the periocular soft tissue of the orbit is a rare manifestation of meta-static cancer. Infiltrating lobular breast cancer (ILBC) is a special breast cancer subtype, which accounts for 10–15% of all mammary carcinomas and for ~1% of all malignancies.

Loss of E-cadherin expression due to mutation of the CDH1 gene is a characteristic feature of invasive lobular breast cancer (ILBC). Beta-catenin, which binds to the cytoplasmic domain of...

2020年7月15日 · A, B Histology of classical invasive lobular breast carcinoma (ILBC), intermediate grade (G2). Discohesive tumor cells are diffusely dispersed as single cells or grow loosely in a linear single-file pattern. A H&E. ×100. B H&E. ×400. C, D Pleomorphic ILBC, high grade (G3) with pleomorphic and hyperchromatic nuclei and increased mitotic activity.

2020年7月15日 · Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular, invasive cribriform, mucinous, and invasive micropapillary carcinomas.

2014年10月30日 · Infiltrating lobular breast cancer (ILBC), is a special breast cancer subtype. ILBCs account for 10–15% of all mammary carcinomas and for ~1% of all malignancies 4. ILBCs display a distinct histomorphology and are almost always estrogen receptor (ER)-positive 5.

A, B Histology of classical invasive lobular breast carcinoma (ILBC), intermediate grade (G2). Discohesive tumor cells are diffusely dispersed as single cells or grow loosely in a linear single-file pattern.

2024年1月24日 · Most invasive lobular breast carcinomas (ILBCs) are luminal‐type carcinomas with an HER2‐negative phenotype (ERBB2 or HER2 un‐amplified) and CDH1 mutations. Rare variants include ERBB2 ‐amplified subtypes associated with an unfavorable prognosis and less response to anti‐HER2 targeted therapies.