IL-15Rα与 IL-2Rβ 和γc链形成高亲和力的三聚体受体，使细胞能够对低浓度的IL-15做出反应。IL-15Rα本身也有能力进行信号转导。 不同的膜结合IL-15因子和sIL-15/IL-15Rα复合物由复合物 …

2024年1月8日 · 白细胞介素-15（interleukin -15，IL-15）是一种T细胞生长因子，于1994年被两个独立的实验室发现，与IL-2具有类似的生物学功能。IL-15 主要由单核细胞和巨噬细胞产生。 …

Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL-15 Rα) in solution, inspired by the natural trans-presentation of IL-15, advances the …

2007年7月22日 · Here we present a 1.85-Å crystal structure of the human IL-15–IL-15Rα complex. The structure provides insight into the molecular basis of the specificity of cytokine …

2025年2月18日 · In April 2024, the FDA approved the interleukin (IL)−15 superagonist, N-803 (Anktiva, nogapendekin alfa inbakicept-pmln), for the treatment of bladder cancer [1].

Herein, we used temperature-controlled pBV220 plasmid encoding Interleukin-15 and its receptor alpha subunit (IL-15&15Rα) to transform VNP20009, an attenuated salmonella typhimurium …

Interleukin (IL)-15 can sustain memory T cell expansion when presented in complex with IL-15Rα (15Rα/15). We developed a novel in-vitro system for generation of stable 15Rα/15 complexes.

Ascitic immune cells reversed immuno-suppressive phenotype could recognize and attack cancer cells. A bioengineered adipocyte, encapsulating long-chain fatty acids and concurrently …

2006年1月20日 · In sharp contrast with this finding, we demonstrate in this report that a recombinant, soluble sushi domain of IL-15Rα, which bears most of the binding affinity for IL …

IL-15 is a 14–15 kDa four-helix bundle cytokine that is crucial for natural killer (NK), NKT and memory (m) CD8 + T cell function and homeostasis. IL-15 is minimally secreted but is …