2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF …

Inflammatory signals, changes in levels of reactive oxygen species, ultraviolet radiation, protein synthesis inhibitors, and a variety of stress stimuli can activate JNK. One way this activation …

JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein …

应激活化蛋白激酶 (sapk)/jun 氨基末端激酶 (jnk) 是 mapk 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 gpcr 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho …

2007年5月1日 · c-Jun N-terminal protein kinases (JNK), also known as stress-activated protein kinases, were originally identified by their ability to phosphorylate the N-terminal of...

2001年11月20日 · Our studies reveal a novel aspect of the regulation of Jnk-signaling, a DSP that may function in the activation of Jnk without effect on Erk and p38 MAPKs. Therefore, it will be …

2008年10月20日 · JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the …

2025年3月13日 · There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or …

6 天之前 · CARD11 is a critically important signaling hub and scaffold protein that controls T cell activation by linking TCR engagement to the activation of the nuclear factor κB (NF-κB), c-Jun …

2024年8月1日 · JNKs are activated through phosphorylation by upstream MAPK Kinases (e.g., MKK4/7), which are themselves activated by MAPK Kinase Kinases (MAP3K). Once activated, …