By activating and inhibiting other small molecules in this way, JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis. JNK1 is involved in apoptosis , neurodegeneration , cell differentiation and proliferation, inflammatory conditions and cytokine production mediated by AP-1 ...

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that …

2005年1月1日 · Emerging evidence suggests that JNK may function as a modulator to “break the brake” on apoptosis, rather as a genetic component of the apoptotic machinery to induce apoptosis.

2016年7月27日 · The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including neuronal functions, immunological actions, an …

2007年8月1日 · JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to contribute to many diseases involving neurodegeneration, chronic inflammation, birth defects, cancer and ischemia/reperfusion injury.

2000年4月15日 · As its full name suggests, Jun N-terminal kinase (JNK, pronounced ‘junk’) is an enzyme that phosphorylates the amino-terminal domain of the Jun transcription factors. JNK is a serine/threonine kinase, a member of the extensive family of MAP kinase proteins critical for signal transduction pathways.

c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function.

JNKs also regulate important physiological processes, including neuronal functions, immunological actions, and embryonic development, via their impact on gene expression, cytoskeletal protein dynamics, and cell death/survival pathways.

2014年4月17日 · A major breakthrough in understanding nuclear JNK function emerged from recent studies showing that JNK directly targets chromatin modifiers, driving histone phosphorylation and acetylation...

2016年1月11日 · JNK’s, particularly JNK3, not only enhance Aβ production, moreover it plays a key role in the maturation and development of neurofibrillary tangles. This review aims to explain the rationale behind testing therapies based on inhibition of JNK signaling for AD in terms of current knowledge about the pathophysiology of the disease.