Neurotrophin binding to p75NTR activates a JNK signaling pathway causing apoptosis of developing neurons. JNK, through a series of intermediates, activates p53 and p53 activates …

2016年7月27日 · Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are …

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。应激反应信号经 Rho 家族（Rac、Rho …

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and …

5 天之前 · The c-Jun N-terminal kinase (JNK) pathway is one of the major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling pathway. It functions in the control of a …

2008年10月20日 · JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the …

2014年4月17日 · JNKs are sensors of stress, eliciting transcriptional responses in the nucleus and intrinsic death pathway responses in the cytosol, which communicate a strong pro-apoptotic …

SAPK/JNK Signaling c-Jun N-terminal kinases (JNKs), also referred to as stress-activated protein kinases (SAPKs), are characterized by their activation in response to cell stress such as UV …

2002年2月1日 · Mitogen-activated protein (MAP) kinase signaling pathways relay, amplify and integrate signals from a diverse range of extracellular stimuli, thereby controlling the genomic …

1 天前 · A close relationship exists between ERS and the JNK signaling pathway. To further verify whether apoptosis induced by the SSA-activated p-JNK signaling pathway is mediated through …