LogP is used in the pharmaceutical/biotech industries to understand the behavior of drug molecules in the body. Drug candidates are often screened according to logP, among other criteria, to help guide drug selection and analog optimization.

Lipophilicity is represented by the descriptors logP (also known as Kow or Pow) and logD, and is used, for example, to help predict in-vivo permeability of active compounds in drug discovery; to anticipate the impact of insecticides, herbicides, and fertilizers on various species in agrochemicals research; to develop environmental profiles of wa...

By contrast, the solubility characteristics of small compounds, such as crosslinkers, biotin- and fluorophore-labeling reagents, and chemical blocking reagents, can be determined easily by …

2017年2月26日 · The Log P value is the logarithm of its partition coefficient between n-octanol and water, is a well-established measurement of a compound’s hydrophilicity.

2023年12月18日 · Results: In this study, the result shows that the applications that have the best correlation with the experimental Log P are ACDlogP, MolLogP, and ALOGPS, with successive results of the R square...

Log P： 在化合物的所有分子均以中性形式存在的 pH条件下，其在一种有机相（例如辛醇）和一种水相（例如缓冲液）中分配系数的对数即为 Log P。 Log P =Log（ [化合物有机相]/ [化合物水相]） Log D： 某一特定的pH（x）下，化合物部分以离子形式存在，部分以中性分子形式存在;此pH下的化合物在一种有机相（例如辛醇）和一种水相（例如缓冲液）中分配系数的对数即为 Log D。 Log DpHx =Log（ [化合物有机相]/ [化合物水相]） Log P值取决于中性分子在两相中的分配情况， …

The distribution coeficient (log P) gives an indication of how easily the drug is adsorbed, how strong the effect is, how long it remains in the body in an active form, and how it is …

LogD is a distribution coefficient widely used to measure the lipophilicity of ionizable compounds, where the partition is a function of the pH. For non-ionizable compounds LogP = LogD throughout pH range, whereas for ionizable compounds LogD takes into account the partition of both ionized and non-ionized forms.

Molecular lipophilicity, usually quantified as log P, is an important molecular characteristic in medicinal chemistry and also in rationalized drug design. The log P coefficient is well-known as one of the principal parameters for the estimation of lipophilicity of chemical compounds and determines their pharmacokinetic properties.

LogP, also known as Kow or Pow, is a measurement of how hydrophilic or lipophilic a chemical substance is. It describes the tendency of a neutral compound to partition between water and organic solvents like lipids. A negative logP value means a compound is more hydrophilic, while a positive value means it is more lipophilic.