2021年6月16日 · To disclose the molecular details that define G-protein recognition and the asymmetric activation of class C GPCRs, we solved the fully active structures of mGlu2 and …

2025年2月13日 · Group II metabotropic glutamate receptors (mGluRs), comprising mGluR2 and mGluR3, are class C GPCRs that play key roles in modulating synaptic transmission via Gi/o …

Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. [5] [6] mGluR2 is a G protein-coupled receptor (GPCR) that couples with the Gi …

We now show that a heteromeric complex between the 2AR and the Gi-linked GPCR, metabotropic glutamate 2 receptor (mGluR2), integrates ligand input, modulating signaling …

通过解析mGluR2跨膜结构域与反向别构调节因子（negative allosteric modulator，NAM）的复合物三维结构，从分子水平分析受体与配体的结合机制，能够为设计特异性强、效力高的药物提 …

mGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are …

mGlu属于C类G 蛋白偶联受体 （G protein-coupled receptor，GPCR）家族，不同于其它类型GPCR，C类GPCR必须形成二聚体，才能发挥功能。 近年来，越来越多的研究表明，mGlu除 …

2019年12月5日 · High sensitivity and an unusually broad dynamic range should enable mGluR2/7 to respond to both glutamate transients from nearby release and spillover from distant synapses.

Here we report two cryo-electron microscopy structures of human mGlu2 and mGlu4 bound to heterotrimeric G i protein. The structures reveal a G-protein-binding site formed by three …

2021年5月13日 · Here we show structures of homodimers of the family C metabotropic glutamate receptor 2 (mGlu2) in distinct functional states and in complex with heterotrimeric G i .