RNA therapeutics are a new class of medications based on ribonucleic acid (RNA). Research has been working on clinical use since the 1990s, with significant success in cancer therapy in the …

2022年5月21日 · In this review, we comprehensively describe mRNA-based therapeutics, including their principles, manufacture, application, effects, and shortcomings.

An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1] The vaccine delivers molecules of antigen …

2014年9月19日 · This Review gives a comprehensive overview of the current state of mRNA drug technologies, their applications and crucial aspects relevant to mRNA based drug discovery …

Our mRNA pipeline shows the progress we’re making on clinical programs currently in development to create mRNA medicines for a wide range of diseases and conditions. Track …

2024年11月14日 · Herein, mainly focused on the linear non-replicating mRNA, we overview the preclinical and clinical progress and prospects of mRNA medicines encompassing vaccines …

2022年3月3日 · Both approved mRNA vaccines against SARS-CoV-2 developed by Moderna (mRNA-1273) and Pfizer/BioNTech (BNT162b2) are formulated in LNPs. Unformulated mRNA …

mRNA vaccines use a piece of mRNA that corresponds to a protein on a virus. Vaccines for COVID-19 are the only mRNA vaccines authorized or approved by the FDA.

Here we review the applications of mRNA-based therapeutics, with emphasis on the innovative design and future challenges/solutions. In addition, we also discuss the next generation of …

mRNA products are therapies that are regulated from the post-transcriptional, pre-translational stage of a gene and act upstream of protein synthesis. Compared with traditional small …