2020年8月24日 · Transcriptome sequencing analysis reveals that anlotinib targets ATP6V0E2 (ATPase H + Transporting V0 Subunit E2) and other lysosome-related genes. We validated that anlotinib treatment activates...

2019年7月8日 · EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. Consistently, EN6...

mTOR (mammalian target of rapamycin) is a serine-threonine kinase belonging to the PI3K/Akt/mTOR signalling pathway that is involved in several cell functions, including growth, proliferation, apoptosis and autophagy. mTOR hyperactivation has been detected in several human cancers, thus representing …

进一步研究发现， 肿瘤微环境中肿瘤细胞糖酵解所产生的乳酸通过激活 mTOR, 从而磷酸化转录因子 TFEB 并抑制其核转位, 从而抑制TFEB靶基因Atp6v0d2表达。

2021年4月8日 · Vacuolar H + -ATPases (V-ATPases) transport protons across cellular membranes to acidify various organelles. ATP6V0A1 encodes the a1-subunit of the V0 domain of V-ATPases, which is strongly...

2019年5月27日 · 免疫荧光染色显示，ATP6V0d2的缺乏降低了溶酶体标记物mTOR和LAMP1的共定位（图1E和1F），表明ATP6V0d2可能促进mTOR向溶酶体膜的募集。

2025年3月30日 · ATP6V1A (ATPase H+ Transporting V1 Subunit A) is a Protein Coding gene. Diseases associated with ATP6V1A include Cutis Laxa, Autosomal Recessive, Type Iid and Developmental And Epileptic Encephalopathy 93. Among its related pathways are Insulin receptor recycling and MITF-M-dependent gene expression.

Here, we found that lactate, a metabolite found in high concentration within the anaerobic tumor environment, activated mTORC1 that subsequently suppressed TFEB-mediated expression of the macrophage-specific vacuolar ATPase subunit ATP6V0d2.

2019年2月5日 · Here, through the use of complementary experimental approaches involving mammalian cells and Saccharomyces cerevisiae, we have demonstrated that mutations in the human v-ATPase subunit ATP6V1B2...

atp6v0d2基因敲除小鼠对DSS诱导的结肠炎和鼠伤寒沙门氏菌诱导的死亡的敏感性，突出了ATP6V0D2介导的自噬小体-溶酶体融合的体内意义。 在一起，我们的数据确定ATP6V0D2是巨噬细胞特异性自噬体-溶酶体融合机制的关键组成部分，可维持巨噬细胞细胞器的稳态，进而限制炎症 …