Regulation and function of mTOR signalling in T cell fate …
2012年4月20日 · Following antigenic stimulation, the TSC complex is inactivated by T cell receptor (TCR) signals, resulting in the activation of mTOR complex 1 (mTORC1), whereas …
mTOR and Other Effector Kinase Signals that Impact T Cell …
In this review we briefly cover canonical TCR signaling to set the stage for discussion on mTOR signaling in T cells, mRNA translation, and metabolic adaptation. We also discuss the role of …
Regulation of CD8+ T memory and exhaustion by the mTOR …
2023年8月15日 · In this review, we focus on mammalian target of rapamycin (mTOR), particularly signaling mediated by mTOR complex (mTORC) 2 in memory and exhausted CD8+ T cells at …
Fatty acid metabolic reprogramming via mTOR-mediated ... - Nature
2016年11月30日 · Here, we demonstrate that the signalling axis of TCR–mTORC1–PPARγ and TCR–mTORC1–SREBP1 is essential for the activation of the fatty acid metabolic programme …
苏冰研究团队在Cellular & Molecular Immunology发表mTOR信号 …
2023年9月26日 · 该综述详细讨论了急性、慢性感染和肿瘤发生条件下CD8+ T细胞分化的异质性以及mTOR (重点阐述mTORC2/SIN1)信号通路在记忆T细胞和耗竭T细胞分化过程中的分子调控 …
mTOR, metabolism, and the regulation of T-cell differentiation …
mTOR is emerging as a critical integrator of environmental cues guiding T-cell differentiation and function. mTOR also plays a critical role in regulating cellular metabolic programs.
综述浅读| mTOR到底是个啥 - 知乎
参与调节mTORC1活性的最重要蛋白质是结节性硬化症复合物TSC（Tuberous Sclerosis Complex）。 而Rheb作为小Ras相关GTP酶，在活性状态下会激活mTORC1。 TSC又通过 …
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
2008年6月3日 · We report that premature termination of TCR signaling and inibition of phosphatidyl inositol 3-kinase (PI3K) p110alpha, p110delta, protein kinase B (Akt), or …
T cell receptor-dependent activation of mTOR signaling in T cells …
2014年6月10日 · Signaling to the mechanistic target of rapamycin (mTOR) regulates diverse cellular processes, including protein translation, cellular proliferation, metabolism, and …
mTOR signaling and transcriptional regulation in T lymphocytes
Here, we review the impacts of mTOR signaling on transcription factors in different aspects of T cell biology, including lymphocyte development, activation and lineage differentiation. The …