mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis. [1] [2]

mTORC1 promotes protein synthesis largely through the phosphorylation of two key effectors, p70S6 Kinase 1 (S6K1) and eIF4E Binding Protein (4EBP) . mTORC1 directly phosphorylates S6K1 on its hydrophobic motif site, Thr389, enabling its subsequent phosphorylation and activation by PDK1.

Dec 28, 2020 · mTORC1 (Mechanistic target of rapamycin complex 1) serves as a molecular hub and intracellular energy sensor that regulate various cellular processes. Emerging evidence points to mTORC1 signaling as a critical regulator of cardiovascular function with implications for cardiovascular disease.

Through a diverse set of downstream targets, mTORC1 promotes the biosynthesis of macromolecules, including proteins, lipids, and nucleotides to build the biomass underlying cell, tissue, and organismal growth. Here, we focus on the metabolic functions of mTORC1 as they relate to the control of cell growth.

mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient signals and the metabolic processes indispensable for cell growth. While ...

mTORC1 and mTORC2 control metabolic processes important for protein synthesis and folding. mTORC1 controls protein synthesis via phosphorylation of the translation regulators S6K and 4EBP1. Both mTORC1 and mTORC2 are also involved in ribosome biogenesis and transport of amino acids that are required for translation.

Aug 23, 2023 · As part of mTOR complex 1 (mTORC1), mTOR integrates signals such as the levels of nutrients, growth factors, energy sources and oxygen, and triggers responses that either boost anabolism or...

Jan 2, 2019 · The mTORC1–S6K1 axis and casein kinase 1 (CK1) coordinately phosphorylate and activate SRPK2, a key RNA-binding regulator in mRNA processing, to modulate splicing of pre-mRNAs encoding...

Oct 2, 2023 · The mTORC1 suppressed the ULK1 complex activity via phosphorylation of ULK1/ATG13. The mTORC1 can help in the translocation of TFEB in the nuclear compartment to regulate the process of...

Jul 1, 2021 · A central signaling molecule that integrates growth with metabolism is the mechanistic target of rapamycin (mTOR). mTOR is a protein kinase that responds to levels of nutrients and growth signals. mTOR forms two protein complexes, mTORC1, which is sensitive to rapamycin, and mTORC2, which is not directly inhibited by this drug.