2024年12月25日 · MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10A include Leukemia, Chronic Myeloid and Myelodysplastic Syndrome. ... GeneHancers around MIR10A on the GeneHancer Hub at the UCSC Golden Path. No Post-translational modifications.

2020年12月1日 · The expression of both miR-10a and its downstream targets were strongly predictive of MDM2 inhibitor sensitivity in cell lines, primary AML specimens, and correlated to response in patients ...

Elevating miR-10a-5p levels inhibited proinflammatory gene expression in cultured RAW 264.7 macrophages and promoted the differentiation of C3H10T1/2 cells into brown adipocytes. Furthermore, treatment with a miR-10a-5p mimic in vivo rescued CL-induced beige adipogenesis in Dicer KO mice.

2009年5月22日 · In the haematopoietic system, miR-10a is normally expressed in CD34 + cells, 24 and in vitro differentiation of CD34 + cells into megakaryocytes is accompanied by a marked decrease in the levels...

探讨微小RNA (miRNA，miR)-10a对胶质瘤细胞生长和迁移的影响及分子机制。 收集脑胶质瘤和癌旁组织，采用荧光定量聚合酶链反应 (PCR)分析miR-10a的表达水平。 在U251脑胶质瘤细胞株中构建miR-10a过表达细胞株 (实验组)和对照细胞株 (对照组)，采用细胞计数试剂盒 (CCK-8)试剂盒和Transwell分析不同处理的脑胶质瘤细胞的增殖和迁移能力。 采用生物信息学和双荧光素酶报告基因分析miR-10a与靶基因的关系；并在miR-10a过表达细胞株过表达靶基因，分析细胞的增 …

2008年5月23日 · We show that miRNA miR-10a interacts with the 5′UTR of mRNAs encoding RPs and enhances their translation. miR-10a binds immediately downstream of the regulatory 5′TOP motif, and the 5′TOP is necessary for miR-10a translational enhancement.

2025年1月6日 · miR-10a/b-5p exhibit dual roles as both TSmiRs and oncomiRs in cervical cancer. miR-10a/b-5p act as tumor suppressors in cervical cancer by targeting key oncogenes and signaling pathways. miR-10a-5p suppresses cancer cell proliferation by directly targeting brain-derived neurotrophic factor (BDNF), thereby inhibiting tumor progression .

2025年3月17日 · The miR-106a-363 cluster, a paralog of the well-known proto-oncogenic miR-17-92 cluster, encodes six miRNAs: miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92a-2, and miR-363 (Supplementary Fig. S1A ...

The upregulation of miR-10a and miR-10b in AML indicated that miR-10a/b may serve as potential biomarkers for diagnosis of AML. Several innate properties of miRNAs make them attractive as potential biomarkers. miRNAs are small and stable against degradation and can be detected easily by specific and sensitive RT-qPCR in small amount samples.

Together these findings demonstrate that miR-10a may be useful as both a biomarker to identify patients most likely to respond to cytarabine+MDM2 inhibition and also a druggable target to increase their efficacy.