In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product.

在一项新的研究中，来自美国宾夕法尼亚大学和康涅狄格大学等研究机构的研究人员发现高脂肪饮食导致小鼠白色脂肪组织中的miR-181激活，随后导致肥胖、胰岛素抵抗性和白色脂肪组织炎症。

2023年4月23日 · This review focuses on the miR-181 family and provides information from the published literature on the role of miR-181 homologs in regulating a range of activities in different cell types and tissues.

2021年4月20日 · 在本综述中，研究者系统回顾了病理和生理状态下miRNAs中高度保守的miR-181 家族，通过总结大量的研究强调了miRNA在调节重要的生物学过程扮演的角色，例如胚胎发育、细胞增殖、凋亡、自噬、线粒体功能以及免疫反应。 重要的是，这一家族的成员参与许多病理过程，例如最常见的神经退行性病变以及许多的实体瘤和血液瘤。 miRNAs家族在病变与可能的影响上的相关性有待进一步探讨。 对于miR-181家族在病理条件下的研究有望为神经退行性病变以及 …

In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions.

2019年5月21日 · 张群研究发现，miR-181a在卵巢早衰患者血清中异常高表达，且在颗粒细胞中表达受H2O2上调；miR-181a通过靶向抑制SIRT1的表达，增加FoxO1乙酰化修饰及细胞核转运，导致颗粒细胞凋亡。 [13] 大量研究表明，除促进细胞凋亡之外，miR-181a对细胞分化也具有促进作用。例如，Naguibneva, I等人研究表明，miR-181a参与小鼠骨骼肌的分化过程，若miR-181a增多，则会促进新生肌肉的增加，若将miR-181a去除，成肌细胞的分化过程则受到抑制。

2013年5月23日 · We revealed that miR-181 was an essential regulator of PI3K signaling strength, through PTEN modulation, and therefore was a critical determinant of cellular metabolic adaptations required for the support of high proliferation rates during development.

2020年5月20日 · Recent studies have demonstrated that the miR-181 family is dysregulated in various tumor tissues and plays a pivotal role in carcinogenesis. They have been shown to act as oncomirs or tumor suppressors considering their mRNA targets and to be involved in cell proliferation, apoptosis, autophagy, angiogenesis and drug resistance.

2014年9月1日 · Here, we report function and mechanisms of miR-181 family in myeloid differentiation and acute myeloid leukemia (AML). The aberrant overexpression of all the miR-181 family members...

2021年10月28日 · We reveal that miR-181 levels predict disease progression in large discovery and replication cohorts and demonstrate the effectiveness of combining miR-181 with established NfL as a prognostic...