miR-205 exerts a tumor-suppressive effect in human prostate by counteracting epithelial-to-mesenchymal transition and reducing cell migration/invasion, at least in part through the down-regulation of protein kinase Cepsilon. [9] miR-205 activated tumor suppressor genes by targeting specific sites in their promoters. These results corroborate a ...

2024年12月25日 · MIR205 (MicroRNA 205) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR205 include Head And Neck Cancer and Squamous Cell Carcinoma. ... Control Lentivectors and Lentiviruses with …

2020年11月15日 · In this review, we summarize the principal mechanisms that regulate miR-205 expression at the transcriptional and post-transcriptional level, with particular focus on the transcriptional...

We have identified miR-205, a versatile and potent regulator of the actin cytoskeleton, whose expression modulates actomyosin contractility and the dynamics of cell size changes.

2025年2月16日 · 为解决卵巢癌（OC）中肿瘤细胞与免疫细胞相互作用机制不明的问题，中南大学 Liuqing He 等人开展肿瘤来源外泌体 miR - 205 对 OC 影响的研究，发现其可促进 M2 巨噬细胞极化推动 OC 进展，为 OC 治疗提供新靶点，值得科研人员阅读。

MiR-205 is a diagnostic and prognostic biomarker that shows high specificity for epithelial cancers, aiding in cancer type classification and origin determination. It is particularly useful in identifying various types of cancers, such as head and neck squamous cancer, lung squamous cell carcinoma, and triple-negative breast cancers.

2020年8月25日 · miRNA 205（miR-205）是一种高度保守的miRNA，可以同时充当癌基因RNA和肿瘤抑制因子。 然而，大多数报道证实了其在许多癌症中作为肿瘤抑制物的新兴作用。 这篇综述着重于miR-205的表达下调，并讨论了其在乳腺癌，前列腺癌，皮肤癌，肝癌，神经胶质瘤，胰腺癌，结直肠癌和肾癌中的失调。 这篇评论还授予了它在肿瘤发生，进展，细胞增殖，上皮向间质过渡，以及肿瘤转移。 恢复miR-205可使细胞对药物治疗更加敏感，并减轻药物耐药性。 另 …

体外培养的HGC27细胞通过转染miR-205 mimic上调细胞中miR-205的表达，划痕实验和Transwell实验观察其侵袭和迁移能力；Western blot检测上皮间质转化（epithelial-mesenchymal transition, EMT）进程及相关信号通路的活性。

2025年2月8日 · miR-205 promoted epithelial-mesenchymal transition progression in cisplatin-resistant nasopharyngeal carcinoma (NPC) cells by PTEN repression via PI3K/AKT signaling pathway. MiR-205-5p was low-expressed while ZEB1 and ADPGK-AS1 were high-expressed in pancreatic cancer (PC) tissues and cells.

2020年8月25日 · This review focuses on the downregulated expression of miR-205 and discusses its dysregulation in breast, prostate, skin, liver, gliomas, pancreatic, colorectal and renal cancers. This review also confers its role in tumor initiation, progression, cell proliferation, epithelial to mesenchymal transition, and tumor metastasis.