In molecular biology MicroRNA-223 (miR-223) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development.

miR-223 是一种高度保守的 miRNA，在多种组织、细胞中均有表达，并且其表达受到 CEBPA 和NFIA 等重要转录因子的调控。 miR-223 对肝脏、脂肪组织和血液中的脂质代谢，如脂蛋白吸收、

MicroRNAs (miRNAs) are diminutive noncoding RNAs that can influence disease development and progression by post-transcriptionally regulating gene expression. The anti-inflammatory miRNA, miR-223, was first identified as a regulator of myelopoietic differentiation in 2003.

2024年12月25日 · MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR223 include Neutrophilia, Hereditary and Leukemia, Chronic Myeloid. Among its related pathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. ...

2021年6月4日 · This review paper summarizes miR-223 biosynthesis and its regulatory role in the differentiation of granulocytes, dendritic cells (DCs) and lymphocytes, macrophage polarization, and endothelial and epithelial inflammation.

miR-223 is a multifunctional miRNA regulated by several transcription factors, and its expression is significantly elevated during cellular or tissue inflammation. miR-223 regulates immune cell proliferation, differentiation and polarization, and has immunomodulatory effects in certain tissues.

2019年6月1日 · miR-223 is an evolutionarily conserved anti-inflammatory microRNA primarily expressed in myeloid cells. miR-223 post-transcriptionally regulates many genes essential in inflammation, cell proliferation, and invasion.

2021年12月10日 · This review summarizes the current understanding of miR-223 physiopathology and highlights the molecular mechanism by which miR-223 regulates immune responses to infectious diseases and how it may be targeted for diagnosis and treatment.

微小RNA-223（miR-223）是一种髓系特异性miRNA，在血小板、血浆、内皮细胞中含量丰富，可通过调控血小板及内皮细胞的多种基因表达及功能，参与CVD发生发展，如动脉粥样硬化、血栓形成，心肌代谢，血管生成等多个环节。

2014年7月1日 · miR-223 expression is a modulator of the hematopoietic lineage differentiation. miR-223 is a biomarker and therapeutic target in cancer and inflammation. miR-223 is deregulated in damaged smooth, skeletal and cardiac muscles. Macrophages export miR-223 towards recipient cells, such as hepatocytes.