miR-27 is known to regulate components involved in numerous types of cancer, including breast [10] [11] and ovarian. [12] miR-27a has been identified as an oncogenic microRNA and, specifically, is highly expressed in breast cancer cells. mir-27b expression is associated with survival in triple negative breast cancer patients. [13]

2019年6月2日 · The miR-27a could be an oncogene or a tumor suppressor in several types of cancer, including colon cancer, pancreatic cancer, breast cancer, bladder cancer and hepatocellular carcinoma. In this review, we discuss the role of miR-27a in tumor biology and clinical significance in detail and offer novel insights into molecular targeting therapy ...

miR-27a/FBW7/c-myc 信号通路在胆管癌的发生发 展中起着重要作用。c-myc 为原癌基因，其编码的 产物是P62 核蛋白，能使细胞无限增殖，导致细胞 的恶性转化[17]，并在胆管癌的发病机制中起着重要 的作用[18]。FBW7 作用于c-myc[19]，而miR27a 又 是FBW7 的主要调控因子[20 ...

2024年12月25日 · MIR27A (MicroRNA 27a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27A include Leukemia and Hepatocellular Carcinoma. Among its related pathways are Interactions between immune cells and microRNAs in tumor microenvironment and miRNAs involved in DNA damage response. ...

2020年3月5日 · We disclose an unprecedented role for miR-27a as a master regulator of cancer metabolism reprogramming that impinges on CRC response to chemotherapy, underscoring its theragnostic properties.

2019年6月2日 · Increasing evidence has confirmed that miR-27a plays a vital role in tumor biology, including polymorphisms, tumorigenesis, proliferation, apoptosis, invasion, migration and angiogenesis. Besides this, miR-27a has vital clinical significance in drug sensitivity, treatment of cancer and patient's prognosis.

2019年9月12日 · In this review, we summarize the recent developments in miR-27a research, analyze the biogenesis and functional features of miR-27a, focus on the key signaling pathways affected by miR-27a in cancer cells, summarize recent clinical research on miR-27a as a biomarker or therapeutic target, and provide directions for further studies.

2024年10月16日 · Elevated miR-27a levels led to the inhibition of cell viability, colony formation capacity, migratory and invasive traits in an in vitro context. The PI3K/AKT/mTOR signaling pathway was identified as a direct target of miR-27a and could reverse the effects induced by miR-27a in MM cells.

2024年10月16日 · MiR-27a plays a diverse role in human cancer by impacting tumorigenesis, proliferation, apoptosis, invasion, migration, and angiogenesis through direct binding to the 3’ untranslated region (3’UTR) of target messenger RNA (mRNA) .

We disclose an unprecedented role for miR-27a as a master regulator of cancer metabolism reprogramming that impinges on CRC response to chemotherapy, underscoring its theragnostic properties.