摘 要：微小RNA-29 (microRNA-29, miR-29)家族成员包括miR-29a、miR-29b 和miR-29c，是一类与器官 纤维化密切相关的小分子RNA。 近年研究发现，多种肿瘤组织中存在miR-29s 的表达紊乱。

2024年12月25日 · MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B1 include Alzheimer's Disease and Aortic Disease. Among its related pathways are Alzheimer's disease and miRNA effects and TNFR1 Pathway. ... Control Lentivectors and Lentiviruses with GFP, RFP, and Luciferase also available.

2024年8月27日 · We showed that miR-29b levels are significantly increased with age in multiple tissues in mice (Fig. 1b). Fig. 1: miR-29 is a candidate driver of gene expression changes in aged mice. a...

2024年11月1日 · MicroRNA-29b (miR-29b) is known for its therapeutic potential as an antifibrotic and anticancer agent. In fibrotic conditions, miR-29b inhibits fibrogenesis by downregulating crucial regulators such as collagens, extracellular matrix proteins and the transforming growth factor-β pathway.

Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as …

miR-29 is a well characterized anti-fibrotic miRNA, and it is comprised of three family members: miR-29a, -29b and -29c [133]. These three family members are generated from two co-transcribed polycistronic primary transcripts encoded from miR-29a/-b1 and miR-29c/-b2 loci located on chromosome 7 and 1 respectively [170,171] .

Increasing evidence has identified the miR-29 family, consisting of miR-29a, miR-29b-1, miR-29b-2, and miR-29c, as key regulators of a number of biological processes. Moreover, their abnormal expression contributes to the etiology of numerous diseases.

2017年5月25日 · In this study, using an miRNA array, we identify miR-29b induction and activity as a novel pathway contributing to muscle atrophy. miR-29b expression is significantly increased in multiple in...

结论 miR-29b作为一种抑癌microRNA，在胆管癌中低表达，过表达miR-29b可以抑制胆管癌细胞增殖，促进细胞凋亡。 1. Department of General Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China; 2. Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China.

2024年11月19日 · 首页 > 学位导航 > 负载过表达miR-29b外泌体的微针贴片在治疗心肌梗死后纤维化的研究