miR-34a suppresses the gene expression of NAMPT, which encodes nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the nicotinamide adenine …

Abstract: MiR-34 family is a series of conservative and non-coding miRNAs. Human miR-34s include miR-34a, miR-34b and miR-34c, which express abnormally in various types of tumors. …

2024年12月25日 · MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Retinoblastoma and Neuroblastoma. Among …

2023年9月5日 · FM-miR-34a potently inhibited proliferation and invasion, and induced sustained downregulation of endogenous target genes for >120 h following in vivo delivery. In vivo …

2014年7月17日 · Early studies have shown that miR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we …

2021年3月7日 · Loss of miR-34a expression occurs in a wide range of solid tumors and hematological malignancies (Bader, 2012). Since miR-34 was identified as a p53 target in …

2017年10月12日 · MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy of miR-34a replacement has been investigated in clinical trials as the first attempt …

We identified miR-34a microRNA (miRNA) as a potent regulator that restricts the cell fate potential of ESCs and iPSCs to a pluripotent state. miR-34a−/− pluripotent stem cells exhibit a …

2014年7月17日 · Early studies have shown that miR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we …

2013年8月18日 · miR-34a为新近发现并备受关注的miRNA之一。 目前的研究. 与调节细胞的增殖与凋亡。 现就近年来miR-34a及其与肿瘤关系的研究进展进行综述。 …