Genetic Features of AML with MLL-Rearrangement and NPM1 …
2020年11月5日 · Background: Acute myeloid leukemias with KMT2A (formerly known as MLL-1) fusion genes (MLL-AML) and those with NPM1 mutations (NPM1-AML) are distinct subtypes …
MLL-Rearranged Leukemias—An Update on Science and Clinical
In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and …
MLL基因重排成人急性髓系白血病的特征和预后分析
mll基因重排的急性髓系白血病（aml）约占成人aml的5%，具有缓解率低、容易复发、预后差的临床特征 。我们对我中心2010年1月至2016年12月收治的mll基因重排aml患者进行了回顾性分 …
MLL基因（ALL1、HRX）异常与白血病 - 血液病学 - 天山医学院
MLL基因（myeloid/lymphoid leukemia或mixed lineage leukemia）也称为 ALL1 （acute lymphocytic leukemia 1）或HRX（homolog of trithorax），具有三个区域与果蝇三胸蛋白同源 …
【Leukemia】KMT2A重排成人AML的突变特征和预后 - MedSci.cn
式MRD监测可以检测高危AML患者的MRD复发，并可通过计算分析（computational analysis）增强其评估，为无监督MRD分析的应用提供了一个平台，以标准化和加强对新发白血病的评估。
Cell丨靶向治疗急性髓细胞性白血病的新方案 - 知乎
急性髓细胞性白血病 (Acute myeloid leukemia, AML) 是一种髓系造血干/祖细胞恶性血癌，主要是因为白血病细胞取代正常骨髓性细胞所致，造成周边血液的红血球、血小板和正常的白血球下 …
MLL Gene Alterations in Acute Myeloid Leukaemia (11q23/MLL+ AML)
2011年11月13日 · AML with MLL gene alterations (11q23/ MLL+ AML) represents 3-4% of all AML cases and occurs most frequently in young people with “ de novo” AML (5-7%) and in …
Molecular pathogenesis of disease progression in MLL -rearranged AML
2018年9月12日 · Among major human acute myeloid leukemias (AMLs), MLL -rearranged AML (MLL -AML) is characteristic of poor prognosis due to refractoriness to chemotherapy and …
Molecular pathogenesis of disease progression in MLL-rearranged AML
Gnb2 mutations (p.G77R) were significantly increased in clone size (P = 0.007) and associated with earlier leukemia onset (P = 0.011). GNB2 transcripts were significantly upregulated in …
MLL gene amplification in acute myeloid leukemia and
MLL gene rearrangements are well-recognized aberrations in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). In contrast, MLL gene amplification in AML/MDS remains …
- 某些结果已被删除