2020年11月5日 · Background: Acute myeloid leukemias with KMT2A (formerly known as MLL-1) fusion genes (MLL-AML) and those with NPM1 mutations (NPM1-AML) are distinct subtypes as defined by the WHO classification. Although they have different clinical features and prognostic impact , recent studies suggest that the MLL1 co-factor, menin, plays a key role in ...

In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and the clinical manifestations of this group of leukemias.

mll基因重排的急性髓系白血病（aml）约占成人aml的5%，具有缓解率低、容易复发、预后差的临床特征 。我们对我中心2010年1月至2016年12月收治的mll基因重排aml患者进行了回顾性分析，现将其特征和预后报道如下。

MLL基因（myeloid/lymphoid leukemia或mixed lineage leukemia）也称为 ALL1 （acute lymphocytic leukemia 1）或HRX（homolog of trithorax），具有三个区域与果蝇三胸蛋白同源。 累及 MLL 基因的白血病既可见于ALL，也可见于AML。 见于AML的MLL异常，除MLL-PTD主要见于M1和M2外，其他的MLL融合基因大多见于M4和M5。 MLL蛋白包括氨基端的AT吊钩、SNL1和SNL2基序以及CxxC结构域，这些结构域通常保留在融合蛋白中。 其中AT吊钩可以特异结 …

式MRD监测可以检测高危AML患者的MRD复发，并可通过计算分析（computational analysis）增强其评估，为无监督MRD分析的应用提供了一个平台，以标准化和加强对新发白血病的评估。

急性髓细胞性白血病 (Acute myeloid leukemia, AML) 是一种髓系造血干/祖细胞恶性血癌，主要是因为白血病细胞取代正常骨髓性细胞所致，造成周边血液的红血球、血小板和正常的白血球下降。随着分子医学的进步，AML的致病基因突变分析检测也取得了长足的发展，但 ...

2011年11月13日 · AML with MLL gene alterations (11q23/ MLL+ AML) represents 3-4% of all AML cases and occurs most frequently in young people with “ de novo” AML (5-7%) and in treatment-induced AML (t-AML) patients (10-15%).

2018年9月12日 · Among major human acute myeloid leukemias (AMLs), MLL -rearranged AML (MLL -AML) is characteristic of poor prognosis due to refractoriness to chemotherapy and shorter period to relapse [1, 2,...

Gnb2 mutations (p.G77R) were significantly increased in clone size (P = 0.007) and associated with earlier leukemia onset (P = 0.011). GNB2 transcripts were significantly upregulated in human MLL-AML compared to MLL-negative AML (P < 0.05), which was supported by significantly increased Gnb2 transcript induced by MLL/AF9 overexpression (P < 0.001).

MLL gene rearrangements are well-recognized aberrations in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). In contrast, MLL gene amplification in AML/MDS remains poorly characterized. Here, we report a series of 21 patients with myeloid neoplasms associated with MLL gene amplificat …