Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma , a monoclonal gammopathy of uncertain significance (MGUS), or further investigate a discrepancy ...

2005年1月1日 · Serum protein electrophoresis is used to identify patients with multiple myeloma and other serum protein disorders. Electrophoresis separates proteins based on their...

2020年7月2日 · Serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) are standard tools for multiple myeloma (MM) routine diagnostics. M-protein is a biomarker for MM that can be quantified with SPE and characterized with IFE. We have investigated combining SPE/IFE with targeted mass spectro …

2020年3月26日 · 97%的MM患者血清蛋白电泳（Serum protein electrophoresis，SPE）中能出现单一峰值或条带，病情好转的大多数MM患者存在低γ球蛋白血症 。 SPE检测. SPE是一种即简单又廉价的筛选方法，推荐采用高分辨率琼脂糖凝胶电泳检测M蛋白。

2020年1月2日 · m蛋白是mm的生物标志物，可以用spe定量并用ife表征。我们已经研究了结合使用spe / ife和靶向质谱（ms）来检测和定量m蛋白。与spe / ife相比，spe-ms分析提供了以更高的灵敏度检测m蛋白的可能性，这可能导致对临床实验室中的最小残留疾病进行更好的分析。

3 天之前 · 多发性骨髓瘤（multiple myeloma，MM）是一种恶性浆细胞病，以骨髓中大量浆细胞恶性增生并产生单克隆免疫球蛋白或其片段（M 蛋白） 为特征（多发性骨髓瘤的“CRAB”症状 ...

In clinical practice, SPE is conducted in the preliminary stage to identify the monoclonal gammopathy as well as the abundance of the M protein in patients with associated signs and symptoms of MM. This study is designed to determine the significance of SPE and immunoglobulins in diagnosing MM.

探讨多发性骨髓瘤 (MM)患者血清轻链 (sLC)κ/λ比值及血清蛋白电泳 (SPE)在MM诊断中的临床价值。 采用速率散射免疫比浊法测定282例MM患者及521例健康对照人群sLC水平并计算κ/λ比值,同时做SPE和免疫固定电泳 (IFE)。 以临床已确诊为MM的患者分型结果为标准,评价sLC比值联合SPE检测对MM诊断的敏感性和特异性。 282例MM患者中145例为IgG型 (IgGκ型83例、IgGλ型62例),73例为IgA型 (IgAκ型34例、IgAλ型39例),19例为IgM型 (IgMκ型14例、IgMλ型5例),45例 …

2020年9月15日 · Multiple myeloma (MM) is diagnosed and monitored by correlating panel of test results including serum Protein electrophoresis (SPE), Immunofixation electrophoresis (IFE), serum Free Light chain (sFLC) measurements.

2025年3月1日 · Solid Phase Extraction (SPE) offers numerous advantages in sample preparation and analytical processes, significantly enhancing the efficiency, sensitivity, and reliability of analytical results. One of the primary benefits of SPE is its ability to concentrate from large volumes of samples, thus improving the detection limits of analytical methods.