2015年8月6日 · Here, we investigated erlotinib response of lung CSCs with WT-EGFR and identified EGFR phosphorylation at tyrosine1068 (EGFRtyr1068) as a powerful biomarker associated with erlotinib...

肿瘤表皮生长因子受体(EGFR)是一个170KDa的跨膜糖蛋白受体酪氨酸激酶，由表皮生长因子激活，影响细胞的生长和分化。 EGFR 家族又称为EGFR酪氨酸激酶家族，由4个不同的受体酪氨酸激酶(PTK)组成，分别为‍EGFR(HER-1/ErbB-1)、ErbB-2(HER-2/neu)、ErbB-3(HER-3) …

Polyclonal Antibody for studying EGFR (Tyr1092) phosphate. Validated for IHC, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-EGF Receptor (Tyr1068) Antibody (CST #2234) is ready to ship.

目的:探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)和磷酸化表皮生长因子受体(phosphorylated epidermal growth factor receptor,P-EGFR)在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC,食管鳞癌)中的表达与其临床病理特征的相关性及预后的关系.方法:采用免疫组织化学 ...

EGFR是上皮生长因子（EGF）细胞增殖和信号传导的受体，激活至少4个主要的下游信号级联，包括RAS-RAF-MEK-ERK, PI3激酶-AKT, PLCgamma-PKC和STATs，也可能激活NF-kappa-B信号级联。 研究表明在许多实体肿瘤中存在EGFR的高表达或异常表达。 EGFR与肿瘤细胞的增殖、血管生成、肿瘤侵袭、转移及细胞凋亡的抑制有关。 广泛表达，但不同样本中的表达量存在明显差异。 异构体2也在卵巢癌中表达。 定位于细胞膜、高尔基体膜、胞内体膜、核膜等。 异构体2属于 …

2021年8月19日 · Phosphorylated-EGFR (p-EGFR) may be more predictive of patient outcome. Recent studies demonstrated that p-EGFR high-expression was associated with poorer prognosis in patients with sarcoma and non-small cell lung cancer .

Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb detects endogenous levels of EGF receptor only when phosphorylated at Tyr1068. This antibody does not recognize EGF receptor phosphorylated at other sites, but may cross-react with other activated ErbB family members. Non-specific staining of smooth muscle may be observed in paraffin-embedded tissues.

Phosphorylated EGFR (p-EGFR) activates cell signaling pathways and has implications in cell cycle, apoptosis, angiogenesis, and cell proliferation. [11, 12] It has been shown that EGFR and p-EGFR are esstential in the carcinogenesis and development of nasopharyngeal carcinoma.

2024年3月28日 · p-EGFR Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects phosphorylated Tyr 1092 of EGFR of human origin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-EGFR monoclonal antibody ...

4 天之前 · 22例egfr突变患者在接受tki治疗期间或之后病情有所进展，其中50%的患者接受过一线化疗失败。 整体客观缓解率（ORR）为43.6% ，中位无进展生存期（PFS）为7.2个月，具体最新疗效结果如下表格：