2019年1月1日 · PKA enhancement of DARPP-32-mediated PP1 inhibition. cAMP activates PKA which phosphorylates DARPP-32 at Thr-34 resulting in DARPP-32-mediated inhibition of PP1. However, DARPP-32 is also phosphorylated by the kinase Cdk5 at Thr-75.

PP1是由催化亚基和调节亚基组成的异二聚酶。人类的催化亚基（PPP1c）有三种编码基因（PPP1CA、PPP1CB和PPP1CC），而调节亚基基因则有20多个。其中一些调节亚基还负责PP1与糖原的结合，所以也称为 糖原靶向蛋白 （protein targeting to glycogen

2000年1月1日 · PP1 is a major eukaryotic protein serine/threonine phosphatase that regulates diverse cellular processes such as cell-cycle progression, protein synthesis, muscle contraction, carbohydrate metabolism, transcription and neuronal signaling [4].

2024年11月6日 · Calcineurin–PP1 and PKA acting at excitatory post-synapses reciprocally regulate sleep duration in mice, whereby PKA promotes wakefulness and calcineurin–PP1 promote sleep.

2024年11月7日 · 该研究揭示了多种酶协同调控睡眠和觉醒平衡的机制，为从分子水平探索控制睡眠时间和睡意的方法提供了重要见解。 为了研究PKA在哺乳动物睡眠调控中的作用，该研究团队构建了敲除PKA各亚基基因的小鼠模型，并分析了其睡眠表型。 结果显示，当敲除抑制PKA磷酸化酶活性的调节亚基Prkar2b基因时，小鼠的非快速眼动 （NREM） 睡眠时间减少，Delta波功率降低。 由于Prkar2b基因的功能是抑制PKA的磷酸化活性，因此敲除该基因可能会导致PKA活性增加 …

Cyclic AMP-dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine- and cAMP-regulated phosphoprotein 32 kD (DARPP-32).

2021年5月15日 · Cyclic AMP–dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine‐ and cAMP‐regulated phosphoprotein 32 kD (DARPP‐32).

2005年1月1日 · PKA-activated PP1 inhibitors consist of one ubiquitously expressed I-1 and one tissue-specific DARPP. They are downstream effectors of Gs-coupled receptors that could activate adenylyl cylases and PKA through extracelluar signals, such as adrenalin and dopamine.

2021年10月21日 · MLCP is a trimeric PP1 holoenzyme, consisting of a PP1∂ isoform and a regulatory complex of MYPT1 (aka MBS, M110) and a 21-kDa accessory subunit, and vital to control cellular phosphorylation in response to various signals .

2024年11月7日 · 使用腺相关病毒 （aav） 介导的 pka 和 pp1-钙调磷酸酶活性刺激，我们表明 pka 是一种促进觉醒的激酶，而 pp1 和钙调磷酸酶起促进睡眠的磷酸酶的作用。