Reciprocal regulation of PKA and Rac signaling | PNAS
We report that Rac1, a member of the Rho GTPase family (25), contains AKAP properties and, thus, show direct interactions with PKA R subunit type IIβ (RIIβ) in vitro and in vivo. Our cell …
cAMP/PKA 介导的体外血管生成：PKA 、 RhoA/ROCK 和 VEGFR2
RhoA 和 Rac1 活性通过慢病毒介导的 RhoA 和 Rac1 的显性阴性 （DN） 和组成型活性 （CA） 形式的过表达进行遗传操纵。 在药理学上，分别通过使用 cAMP 类似物 N6-苯甲酰-cAMP …
Interplay of PKA and Rac: Fine-tuning of Rac localization and …
We demonstrated that GTP-activated Rac acts as a dual kinase-tuning scaffold for p21-activated kinase (PAK) and PKA activities. We showed that receptor-triggered PKA trans …
Nature | 突变型RAS调控细胞巨胞饮过程促进肿瘤生长 - 知乎
该研究发现 RAS通过 腺苷酸环化酶 激活蛋白激酶A（PKA），以此促进V-ATPase从细胞内膜向细胞质膜转运。 V-ATPase在细胞质膜上积累对于激活胆固醇依赖性浆膜结合的RAC1是必需 …
cAMP/PKA-mediated in vitro angiogenesis: A novel interplay between PKA ...
2024年10月28日 · These pro-angiogenesis activities were abrogated by highly specific cell-permeable peptide inhibitor (PKI) of PKA. Activation of cAMP/PKA-signalling resulted in an …
Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1…
2021年11月8日 · Western blot results indicated that Rac1/Cdc42 phosphorylation decreased after CDH12 knockdown (Figure 3E), and 8-Bro (PKA agonist) rescued Rac1/Cdc42 …
Interplay of PKA and Rac - PMC - National Center for …
2013年10月1日 · We demonstrated that GTP-activated Rac acts as a dual kinase-tuning scaffold for p21-activated kinase (PAK) and PKA activities. We showed that receptor-triggered PKA …
细胞骨架和cAMP_PKA信号通路的互动效应调控细胞行为的研究进 …
2016年4月18日 · 此外, 最新研究表明, 除了PTP-PEST, PKA还可 以通过刺激P21活化激酶(p21-activated kinase, PAK) 来调节Rac1活性[27-28]。 PAK作为一种丝氨酸/苏氨酸 激酶, 在肿瘤组 …
Interplay of PKA and Rac: fine-tuning of Rac localization and
Molecular switches such as kinases and GTPases are engaged in versatile PPI. Recently, we have identified dynamic interaction and reciprocal regulation of cAMP-dependent protein …
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine ...
2016年3月18日 · PKA affects cell migration potentially through spatiotemporal interactions with regulators of Rho GTPases. Here we show that the endogenous regulatory (R) subunit of type …