2011年5月15日 · Ensuing PKA phosphorylation of RhoA and the resulting increased interaction between RhoA and RhoGDI (Rho GDP-dissociation inhibitor) establish a negative feedback mechanism that controls the...

2023年1月11日 · RhoA is a downstream effector of PKA and enhances endothelial contractility. Inhibition of RhoA activity via PKA facilitates endothelial relaxation and tightens endothelial cell–cell...

在内皮细胞(endothelia cell)和平滑细胞中，PKA可以抑制小G蛋白Rho(RHOA), 从而最终调节肌球蛋白 MLC ，来松弛肌细胞。 在 心肌细胞 中(cardiac myocyt)，PKA可以通过调节肌钙蛋白( TnI )和心脏磷蛋白( PLB )来调节心肌细胞Lusitropy（松弛）和Inotropy（收缩）。

2011年8月9日 · PKA activity near the leading edge of protrusions phosphorylates RhoA and inhibits its activity via increased association with RhoGDI. Oscillatory cycles of membrane protrusion and retraction at the leading edge are a common feature of cell migration.

Protein kinase A (PKA) inhibits RhoA signaling and thereby induces a characteristic morphological change, cell rounding. This has been considered to result from cAMP-induced phosphorylation of RhoA at Ser-188, which induces a stable RhoA-GTP …

cAMP/PKA 信号转导激活导致 VEGFR2 和 Akt 磷酸化增加，Rac1 活性增加，并强烈抑制 RhoA/Rock 通路。 RhoA 的药理学激活但不抑制 Rac1 消除了 PKA 诱导的 VEGFR2 磷酸化、管形成和 3-D 球体。

Much evidence indicates that cAMP-dependent protein kinase (PKA) prevents increased endothelial permeability induced by inflammatory mediators. We investigated the hypothesis that PKA inhibits Rho GTPases, which are regulator proteins believed to …

2024年10月28日 · We describe for the first time a novel interplay between PKA, RhoA/ROCK, Akt, and VEGFR2 signalling and angiogenesis. Inhibition of RhoA/ROCK plays an important role in mediating PKA-induced angiogenesis and activation of RhoA/ROCK signalling may offer an important target to intervene therapeutic angiogenesis.

A new study shows that protein kinase A (PKA) activity establishes a signaling loop that governs protrusion–retraction cycles in migrating cells. PKA activity near the leading edge of protrusions phosphorylates RhoA and inhibits its activity via increased association with RhoGDI.

2006年4月15日 · As a negative component of PCP signaling, PKA inhibits not only the activation of RhoA and JNK but also the Dsh-Daam1-RhoA complex formation which is essential for the regulation of RhoA activity. Together, our study suggests a molecular pathway from Wnt/Dsh/PKA signaling to Rho activation in PCP signaling.