2024年3月1日 · Furthermore, our pharmacological approaches uncover that signaling mediated by epidermal growth factor receptor (EGFR) and protein kinase A (PKA) control RanBP1 localization during stress. In particular, pharmacological inhibitors of EGFR or PKA diminish the oxidant-dependent relocation of RanBP1.

Because cAMP activates the cAMP-dependent protein kinase A (PKA), we investigated the effect of PKA on the EGFR. The purified catalytic subunit of PKA (PKAc) stoichiometrically phosphorylated the purified full-length wild type (WT) and …

2016年5月1日 · Not only LAPTM4B and TKIs arrest EGFR at nondegradative endosomes, but other stress inducers, such as UV irradiation, cisplatin treatment, hypoxia, oxidative stress, and protein kinase A (PKA) inhibition, also stimulate EGFR internalization and endosomal arrest, although the underlying mechanisms are stress dependent.

2014年8月1日 · In particular, a number of studies demonstrate that cAMP/PKA activity, and hormones that stimulate Gα s-coupled receptors that trigger such activity, have the potential to transactivate the epidermal growth factor receptor (EGFR), thereby promoting the many signals triggered by tyrosine phosphorylation [1], [2], [3], [4], [5], [6], [7], [8 ...

Here, we report that EGFRvIII (ΔEGFR/de2-7EGFR), a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in clinical GBM tumors, promotes glioma growth and invasion through protein kinase A (PKA)-dependent phosphorylation of Dock180, a bipartite guanine nucleotide exchange Factor (GEF) for Rac1.

2021年8月25日 · Ligand-independent epidermal growth factor receptor (EGFR) endocytosis is inducible by a variety of stress conditions converging upon p38 kinase. A less known pathway involves phosphatidic acid (PA) signaling toward the activation of type 4 phosphodiesterases (PDE4) that decrease cAMP levels and protein kinase A (PKA) activity.

Furthermore, our pharmacological approaches uncover that signaling mediated by epidermal growth factor receptor (EGFR) and protein kinase A (PKA) control RanBP1 localization during stress. In particular, pharmacological inhibitors of EGFR or PKA diminish the oxidant-dependent relocation of RanBP1.

此外，我们的药理学方法发现，表皮生长因子受体 (egfr) 和蛋白激酶 a (pka) 介导的信号传导在应激期间控制 ranbp1 定位。 特别是，EGFR 或 PKA 的药理学抑制剂可减少 RanBP1 的氧化剂依赖性重新定位。

Ligand-independent epidermal growth factor receptor (EGFR) endocytosis is inducible by a variety of stress conditions converging upon p38 kinase. A less known pathway involves phosphatidic acid (PA) signaling toward the activation of type 4 phosphodiesterases (PDE4) that decrease cAMP levels and pro …

2003年2月21日 · In this report we demonstrate that these effects of cAMP are mediated via activation of protein kinase A (PKA). Chemical inhibition of PKA suppressed forskolin-induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells.