This gene is a member of the plant homeodomain (PHD) -like finger (PHF) family. It encodes a protein with two atypical PHD-type zinc finger domains, indicating a potential role in …

2024年12月25日 · This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role …

Neurofibrillary tangles (NFTs) are intracellular aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is …

2014年10月24日 · We provide evidence that PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of rDNA promoter and by recruiting H3K9me2/3 …

2015年12月4日 · In the brains of individuals with AD, tau is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs), which manifest as neurofibrillary tangles …

2020年1月1日 · We find that loss of PHF 6 dramatically compromises checkpoint recovery in G2 phase cells. Moreover, PHF 6 is rapidly recruited to sites of DNA lesions in a PARP …

2021年2月24日 · Here, we demonstrated that phosphorylated tau at Ser 396/404 sites, epitope known as PHF-1, is increased in the hippocampus of aged mice at the same time that …

2024年12月25日 · This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and …

2019年6月6日 · Recurrent inactivating mutations have been identified in the X-linked plant homeodomain finger protein 6 (PHF6) gene, encoding a chromatin-binding transcriptional …

2024年2月5日 · PHF-1 is often used to assess the progression of tau pathology in human disease and in the brains of animal models of tauopathy. The antibody recognizes tau in the brains of …