CX-5461 is a DNA G-quadruplex stabilizer with selective ... - Nature
Feb 17, 2017 · Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be repurposed to target DNA …
靶向启动子G-四联体：一种新的抗癌策略？ - 搜狐
Jan 11, 2019 · 生物信息学研究表明，在人体内大约有37万个可以形成G-四联体的基因序列，它们位于双链DNA的延伸区域，特别是在人体端粒末端和癌基因启动区域能够形成G-四联体的序 …
G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in
The propensity of rDNA that is rich in guanine bases to form G-quadruplexes (G4) is discussed and evaluated in disease pathogenesis. Targeting G4 in the ribosomes and other …
The regulation and functions of DNA and RNA G-quadruplexes
Apr 20, 2020 · In this Review, we first discuss the identification of G4s and evidence for their formation in cells using chemical biology, imaging and genomic technologies. We then discuss …
The G4 Genome - PMC
We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the …
G4 Structures in Control of Replication and Transcription of rRNA …
Oct 8, 2020 · Here, we present examples of rDNA promoter regions with extremely high potential to form G4 in two model plants, Arabidopsis thaliana and Physcomitrella patens. The high G4 …
G-rich telomeric and ribosomal DNA sequences from the fission …
In this study, we focused on two different G4 motif-enriched regions; rDNA and telomeres (7). G4 structures are stabilized by the presence of cations, such as Na + and K +, and the stability …
2025年2月17日范衡宇实验室在Science Bulletin发文揭示DExD/H …
ATAC-Seq进一步揭示，虽然整体染色质开放性在转录起始位点（TSS）和rDNA编码区域显著降低，但是G4基序（G4 motif）却在显著富集。 同时，RNA-seq揭示了DHX36在维持母源转录本 …
G4 Structures in Control of Replication and Transcription of
Oct 8, 2020 · Here, we present examples of rDNA promoter regions with extremely high potential to form G4 in two model plants, Arabidopsis thaliana and Physcomitrella patens. The high G4 …
G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in …
Sep 1, 2021 · G4-resolving helicases help preserve rDNA stability by facilitating replication of rDNA repeat regions prone to form G4 structures. 5′-3′ helicases such as FANCJ, RTEL1, and …