The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. [5] The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride. [6] As with other dopamine receptor subtypes, the D 4 receptor is activated by the neurotransmitter dopamine.

The human dopamine receptor D4 (DRD4) gene, located near the telomere of chromosome 11p, exhibits an unusual amount of expressed polymorphism. It contains a 48-bp Variable Number Tandem Repeat (VNTR) polymorphism in the third exon [11], repeated between 2 and 11 times, with the most common versions being 2 (2R), 4 (4R) and 7 (7R) repeats.

2019年9月13日 · DRD4 is the gene that codes for the building of the Dopamine 4 receptor, a G Protein usually found on the postsynaptic membrane throughout the mesocorticolimbic projections. There are...

多巴胺受体D4 是一种由 DRD4 基因编码的 G蛋白偶联受体。 [6] 和其他 多巴胺受体 亚型一样, D 4 受体由 神经递质 —— 多巴胺 激活。 它与 精神分裂症, 帕金森症, 躁郁症，上瘾行为，以及诸如 厌食症, 贪食症 和 暴食症 等 神经性进食紊乱症 等许多神经学或心理学状况相关。 此受体也是许多治疗 精神分裂症 和 帕金森症 的靶标. D 4 受体被认为与 D 2 -类似，被激活的受体抑制 腺苷酸環化酶，从而减少细胞内第二信息递质 环磷腺苷 的浓度。 [7] 此人体蛋白由 11号染色体 上位于 …

2024年12月24日 · DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include Attention Deficit-Hyperactivity Disorder and Autonomic Nervous System Disease. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human DRD4 gene polymorphisms ...

Gene ID: 1815, updated on 8-Feb-2025. This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.

2025年2月8日 · Gene target information for DRD4 - dopamine receptor D4 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The human dopamine D4 receptor (DRD4) is a candidate gene of great interest in molecular studies of human personality and psychiatric disorders. This gene is unique in having an exceptionally high amount of polymorphic sites both in the coding and in the promoter region.

2016年9月14日 · This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.