Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. [5] BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine -cytokine receptor interaction.

13 小时之前 · The combination of FNS and rhBMP-2 for treating femoral neck fractures is minimally invasive and easy to perform and offers greater stability. This approach promotes fracture healing with minimal ...

2013年11月15日 · 在表达产物活性的研究中，以重组的人BMP-2（rhBMP-2）最重要。 单独使用rhBMP-2可诱导具有骨髓的新板层骨的形成。 其它重组hBMP可能与rhBMP-2有协同关系，共同参与了诱导骨生成过程。

The combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an absorbable collagen sponge (ACS) carrier has been shown to induce bone formation in a number of preclinical and clinical investigations.

2023年9月29日 · In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery...

The most frequent primary diagnostic indication for rhBMP-2 use was degenerative disc disease (DDD; 129/400; 32.3% of patients) followed by spondylolisthesis (119/400; 29.8%), deformity (59/400; 14.8%) and pseudoarthrosis (29/400; 7.3%).

2023年8月24日 · This review presents the status of rhBMP-2 use in maxillofacial surgery, focusing on its clinical application, efficacy, safety, and limitations. Studies have demonstrated rhBMP-2’s potential to reduce donor site morbidity and increase bone height in sinus and ridge augmentation; however, it may not outperform autogenous bone grafts.

由创伤,感染,肿瘤,骨质疏松症等引起的骨科疾病严重影响人类健康.近年来,伴随着人口老龄化的加剧,使得这一形势更为严峻.骨形态发生蛋白-2(bmp-2)作为已知成骨活性最高的生长因子之一,在促进骨修复和骨再生过程中发挥重要作用.然而,体内半衰期短以及高剂量 ...

rhBMP-2 showed the potential to be an effective therapeutic option for treatment of many trauma and craniofacial bone defects. Future studies, investigating the long-term effects of rhBMP-2 in large samples, may help to provide scientific evidence in trauma treatment.

2019年8月19日 · Recombinant human bone morphogenetic protein-2 (rhBMP-2) is one of the most commonly used osteogenic agents in the craniofacial skeleton. This study reviews the safety and efficacy of rhBMP-2 as applied to craniofacial reconstruction and assesses the level of scientific evidence currently available.