【摘要】 RpoS （σs 或 σ38）是迄今发现的 E.coli 的7种转录起始因子之一，可在 E.coli 生长率下降、进入静止期或受到饥饿、热击、低温、高渗、氧化等环境压力时被诱导表达，从而或直接或间接的促进或抑制上千个基因的转录，以使 E.coli 能够对（现存和未来可能遇到的）多种环境压力做出响应。 RpoS主导的一般压力反应伴有能耗且若不当开启会导致细胞适合度的下降。 因此，在 E.coli 中，RpoS受到极其严格和复杂的调控。

In this review, I review the origin of RpoS and assess recent transcriptomic and proteomic studies to identify features of the RpoS regulon in specific clades of E. coli to identify core functions of the regulon and to identify more specialized potential roles for the regulon in E. coli subgroups.

The stress sigma factor sigmaS/RpoS counteracts fur repression of genes involved in iron and manganese metabolism and modulates the Ionome of Salmonella enterica serovar Typhimurium.

2024年3月4日 · In E. coli however, the most important alternative sigma factor for general stress tolerance is σ S, also termed RpoS or σ 38 (annotated as RpoS throughout this review). This sigma factor is encoded by the rpoS gene and allows E. coli to simultaneously respond to a large variety of stresses, a response termed the “general stress response” (GSR).

2022年3月31日 · In many Gram-negative bacteria, the stress sigma factor of RNA polymerase, σ S /RpoS, remodels global gene expression to reshape the physiology of quiescent cells and ensure their survival under non-optimal growth conditions. In the foodborne pathogen Salmonella enterica serovar Typhimurium, σ S is also required for biofilm formation and virulence.

2011年7月28日 · The two main RpoS-regulated defenses against oxidative stress are Dps, a DNA-binding protein that sequesters iron and protects DNA from damage, and KatE, one of two hydroperoxidases found in E. coli. KatE is induced in stationary phase and is …

2010年5月27日 · The RpoS sigma factor in proteobacteria regulates genes in stationary phase and in response to stress. Although of conserved function, the RpoS regulon may have different gene composition across species due to high genomic diversity and to known environmental conditions that select for RpoS mutants.

2022年3月31日 · In many Gram-negative bacteria, the stress sigma factor of RNA polymerase, σS/RpoS, remodels global gene expression to reshape the physiology of quiescent cells and ensure their survival under non-optimal growth conditions. In the foodborne pathogen Salmonella enterica serovar Typhimurium, σS is als …

Escherichia coli, in which iron metabolism is particularly well understood, contains at least 7 iron-acquisition systems encoded by 35 iron-repressed genes. This Fe-dependent repression is mediated by a transcriptional repressor, Fur (ferric uptake regulation), which also controls genes involved in other processes such as iron storage, the ...

Several newly identified rpoS-dependent genes are involved in the uptake and metabolism of amino acids, sugars, and iron. Indeed, the rpoS mutant strain shows severely impaired growth on some sugars such as fructose and N-acetylglucosamine.