2021年6月30日 · Upon acute ischemic stroke, rapid recanalization of the occluded cerebral vessel via intravenous thrombolytic therapy (IVT) is crucial to achieve good functional outcome. The time window of IVT with recombinant tissue plasminogen activator (rt-PA) has been extended from post-stroke 3 to 4.5 hours.

2022年5月17日 · Purpose: This research is aimed at systematically assessing the safety and effectiveness of intravenous thrombolysis (IVT) with rt-PA plus human urinary kallidinogenase (HUK) for acute ischemic stroke (AIS). Methods: The data were obtained through rigorous searching of both domestic and foreign databases from inception to 2021.7.1. Randomized ...

2023年7月28日 · 新指南推荐8： 对于发病3小时以内的AIS患者，应进行静脉rt-PA溶栓治疗（Ⅰ类推荐，A级证据）；对于发病3~4.5小时的AIS患者，推荐rt-PA静脉溶栓治疗（Ⅰ类推荐，B级证据）。

In 2005, intravenous (IV) thrombolysis using alteplase, a recombinant tissue-type plasminogen activator (rt-PA), for patients with acute ischemic stroke was approved in Japan on the basis of the results of the Japan Alteplase Clinical Trial (J-ACT) 1) with a specific low-dose regimen.

Results: Intravenous thrombolysis with rt-PA resulted in a better treatment outcome of patients versus aspirin plus clopidogrel (P<0.05). Patients with rt-PA exhibited better improvement in neurological function than those with aspirin plus clopidogrel, as shown by the lower NIHSS scores (P<0.05).

2022年12月16日 · 静脉溶栓（IVT） 是目前治疗AIS的首选方法，基于临床对于提高静脉溶栓总体疗效的需求，以及银杏内酯抗氧化、抗炎和抗血栓作用机制对于静脉溶栓总体疗效的增强。 由浙江大学第二附属医院楼敏教授团队牵头的GIANT研究将银杏内酯注射液与阿替普酶联用，旨在探讨联合用药对接受静脉内（IV）重组组织纤溶酶原激活剂（rt-PA）的患者神经功能的影响。 该研究近日发表在《Frontiers in Pharmacology（IF5.9879）》（药理学前沿）上。 方法. 这项集群随 …

Objective: This study investigated the predictive value of serum MDA and 4-HNE levels on early neurological deterioration (END) after recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients. Methods: This study analyzed 287 AIS patients with standard-dose rt-PA IVT. Clinical ...

To investigate the feasibility and safety of remote ischemic postconditioning (RIPC) in acute ischemic stroke patients after intravenous recombinant tissue plasminogen activator (rt‐PA) thrombolysis (IVT). We performed a pilot randomized trial ...

2022年7月27日 · Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the most effective therapy for the AIS and is recommended by clinical guidelines [1, 2], however, the recanalization rate following the IVT with rt-PA is only about 46%, and there are still about 14-34% of vascular re-occlusion in patients after ...

2019年1月16日 · To investigate the feasibility and safety of remote ischemic postconditioning (RIPC) in acute ischemic stroke patients after intravenous recombinant tissue plasminogen activator (rt‐ PA) thrombolysis (IVT). We performed a pilot randomized trial involving acute ischemic stroke patients with IVT.