Small Interfering RNA (siRNA) Therapy - StatPearls - NCBI Bookshelf
2024年3月20日 · This activity focuses on small interfering RNA (siRNA) therapy, exemplified by FDA-approved agents such as patisiran, givosiran, lumasiran, inclisiran, nedosiran, and vutrisiran.
Therapeutic siRNA: state of the art | Signal Transduction and …
2020年6月19日 · RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making...
A Comprehensive Review of Small Interfering RNAs (siRNAs): …
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized exogenously to create siRNA, which triggers RNA interference (RNAi) in cells and silences target gene expression in a sequence-specific way.
siRNA: Mechanism of action, challenges, and therapeutic approaches
2021年8月15日 · Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions. The mechanism of action of small interfering RNA (siRNA) is based on post-tr …
Therapeutic siRNA: state of the art - PMC - PubMed Central (PMC)
RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising therapeutic ...
Small interfering RNA (siRNA)-based therapeutic applications …
2023年10月16日 · siRNA therapies are flexible approaches to viral infection treatment. RISC-mediates cleavage of virally encoded cytoplasmic mRNAs to inhibit virus replication. Exogenous siRNAs degrade viral RNAs via RNAi pathways . As soon as the genome of a novel virus is identified, RNAi is a reliable infection-mitigating strategy. siRNA-based RNAi therapies ...
Small interfering RNAs (siRNAs) in cancer therapy: a nano …
siRNA has been investigated as an effective treatment for the viral disease as well as cancer extensively with the aim of blocking multiple disease-causing genes. 39 RNAi was discovered for the first time in the nematode Caenorhabditis elegans; however, this process has been also found in many different eukaryotes species including, vertebrates ...
siRNA: Mechanism of action, challenges, and therapeutic …
2021年8月15日 · Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions.
Therapeutic siRNA: State-of-the-Art and Future Perspectives
These are mainly based on an siRNA conjugation with a targeting moiety for liver hepatocytes, N-acetylgalactosamine, and cover the treatment of acute hepatic porphyria, transthyretin-mediated amyloidosis, hypercholesterolemia, and primary hyperoxaluria type 1.
siRNA therapeutics: a clinical reality - PubMed
Herein, we highlight the breakthroughs in siRNA therapeutics, with special feature on the first FDA approved RNAi therapeutics Onpattro (Patisiran) and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical trials.