The associations of NSUN2/IGF-II signature with the risks of death and relapse remained significant in multivariate Cox regression models. Random-effects meta-analyses show the upregulated NSUN2 and IGF-II expression in ovarian cancer versus normal tissues.

The methylation of tRNAs prevents tRNAs from endonucleolytic cleavage by angiogenin to generate tRNA-derived fragments (tRFs), consequently controlling the efficacy of protein translation [16–20], and leading to cytokine production and cellular metabolic changes in response to stress .

2017年8月22日 · The associations of NSUN2/IGF-II signature with the risks of death and relapse remained significant in multivariate Cox regression models. Random-effects meta-analyses show the upregulated NSUN2 and IGF-II expression in ovarian cancer versus normal tissues.

2023年7月15日 · Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1

2023年3月1日 · The aging process is regulated by several pathways, among others insulin/IGF-1 (insulin-like growth factor 1), the mammalian target of rapamycin (mTOR) or AMP-activated protein kinase (AMPK) pathways. The IGF-1 pathway regulates the …

The mRNA codon is read by its cognate transfer RNA (tRNA) in the decoding center (DC). The peptide bond formation occurs at peptidyl transferase center (PTC). The incoming aminoacyl tRNA enters in the A site, the P site holds the peptidyl tRNA, deacetylated tRNA binds the E site before it dissociates from the ribosome.

In this study, we explore repetitive long-term oral delivery of a protein drug using human Insulin-like growth factor (IGF-1) as a novel therapeutic PD for musculoskeletal diseases. IGF-1, upon binding to the IGF-1 receptor, is a major player in skeletal muscle and bone development, growth, and maintenance of physiological strength.

2024年11月12日 · IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance.

摘要： 胰岛素样生长因子（insulin-like growth factors，IGFs）是一个多功能的生长因子家族，对细胞的生长、分化和凋亡起着重要的调节作用。 概述近年来在IGFs的成分、结构功能、信号通路以及在疾病中的作用等方面的研究进展，以期为细胞生长调控、动物胚胎发育及肿瘤发生等方面的研究提供参考。 Abstract: Insulin-like growth factors（IGFs）is a multifunctional growth factor family, and plays an important role in cell growth, differentiation and apoptosis.

2017年8月22日 · The tRNA methytransferase NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates CDK1 expression in a cell cycle-dependent...