TIE2受体是一种酪氨酸激酶受体，含有表皮生长因子同源基序、免疫球蛋白样环和纤维连接蛋白III型重复序列，在内皮和造血干细胞中表达，并与四种血管生成素结合。 TIE2受体广泛表达 …

In cancer, Tie2 was originally found to be overexpressed in tumoral vessels. More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular …

Here we review the importance, and ways to inhibit the function, of one therapeutic target: the receptor Tie2. Tie2 is a receptor present on the cell surface of several cell types within the …

2020年5月14日 · Targeting this newly identified ERβ/ANGPT-2/Tie-2 signaling pathway with the FDA-approved anti-estrogen, Faslodex, may help in the development of a novel combined …

2017年5月19日 · Angiopoietin ligands (ANG1–ANG4) and the TIE (TIE1 and TIE2) receptor tyrosine kinases form an endothelial signalling pathway that is necessary for embryonic …

2020年9月27日 · Tie2阳性单核巨噬细胞(Tie2 expressing monocytes/macrophages, TEMs)是表达酪氨酸激酶受体Tie2(tyrosine kinase receptors with immunoglobulin and EGF homology …

2016年1月19日 · We found that this Tie-2High population exists mainly in prostate cancer cell lines that are capable of metastasizing to the bone. These cells not only express a higher level …

In this study, we show that Tie-2 is expressed by a rare population of prostate cancer cells that co-express several CSC markers. Compared to the Tie-2 Low population, Tie-2 High prostate …

Studies have shown that the overexpression of ANGPT2 and higher ANGPT2/ANGPT1 ratios, compared with normal tissues, correlated with poor prognosis in many cancers, including …

TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as …