PKSs can be classified into three types: Type I PKSs are large, complex protein structures with multiple modules which in turn consist of several domains that are usually covalently …

Here, we used the web tool NaPDoS2 to assess type I polyketide synthase (PKS) diversity and distributions by detecting and classifying ketosynthase (KS) domains across 137 …

根据不同的酰基转移酶(Acyltransferase，AT)结构域，I型PKS可分为顺式-AT (cis-Acyltransferase，cis-AT)型PKS和反式-AT (trans- Acyltransferase，trans-AT)型PKS，目前cis …

2023年9月28日 · 科研人员正迫切期待着进一步理解type I iPKSs，最终创造具备可编程功能的分子机器，产生个性化、定制化的终产物与新型药物。 该研究得到了国家重点研究发展计划、国 …

Polyketides constitute one of the largest families of natural products and many are biosynthesized by noniterative type I polyketide synthases (PKSs). Type I PKSs are multifunctional enzymes …

Type I fatty acid synthases (FASs) are giant multienzymes catalyzing all steps of the biosynthesis of fatty acids from acetyl- and malonyl-CoA by iterative precursor extension. Two strikingly …

2020年3月26日 · Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which can act either iteratively or via an assembly-line mechanism. Domains in the …

2019年2月20日 · Polyketides are constructed from simple carboxylic acid-derived components, often by filamentous bacteria using modular type I polyketide synthases (PKSs), gigantic …

2018年10月17日 · PKSs produce a variety of complex and potent secondary metabolites; they either act iteratively (iPKS), or are linked via directed substrate transfer into modular assembly …

The diverse structures of polyketide natural products are reflected by the equally diverse polyketide biosynthetic enzymes, namely polyketide synthases (PKSs). Three major classes of …