2022年8月3日 · Vaccine-associated paralytic poliomyelitis (VAPP) is an adverse event following exposure to OPV. OPV is made with live attenuated (weakened) polioviruses that can cause sporadic and rare cases of paralytic polio. IPV, the only polio vaccine used in the United States since 2000, carries no risk of VAPP.

2022年9月20日 · A vaccine-derived poliovirus (VDPV) is a strain related to the weakened live poliovirus contained in oral polio vaccine (OPV). If allowed to circulate in under- or unimmunized populations for long enough, or replicate in an immunodeficient individual, the weakened virus can revert to a form that causes illness and paralysis.

2022年2月26日 · OPV与IPV两种疫苗相比较，OPV在罕见情况下可发生疫苗相关麻痹型脊灰（VAPP）和疫苗衍生脊灰病毒（VDPV）病例，IPV没有发生VAPP与VDPV的风险，但在建立肠道免疫方面OPV比IPV效果好。 此外，IPV生产成本更高，价格较昂贵。 3） 含IPV组份的五联疫苗. 五联疫苗同时包含了百白破（百日咳、白喉、破伤风）疫苗、脊髓灰质炎灭活疫苗，和b型流感嗜血杆菌（Hib）疫苗，也就是常说的“一苗防五病” 。 二、脊灰疫苗接种接种方法. 1）接种方法. …

Vaccine-associated paralytic polio (VAPP) occurs in approximately 1 in 2.7 million doses of OPV administered, usually at the first dose. There are no secondary cases or outbreaks associated with VAPP. Mixture of inactivated, killed strains of all three poliovirus types. Body produces antibodies in the blood in response to the inactivated virus.

OPV is made with live attenuated (weakened) polioviruses that can result in a case of vaccine-associated paralytic polio (VAPP) in approximately 1 in 2.7 million doses of OPV. VAPP is caused by a strain of poliovirus that has genetically changed in the intestine from the original attenuated vaccine strain contained in OPV.

vapp病例的病原体是疫苗株病毒，患者可以是受种者本人，或者是与受种者密切接触者。 VDPV的病原体是疫苗株病毒经受种者排出后在自然环境中存活，期间还可能通过感染一系列健康人群后，再感染患者致其发病，患者通常与受种者没有明显的流行病***系。

2020年5月15日 · OPV is made with live attenuated (weakened) polioviruses that can result in a case of vaccine-associated paralytic polio (VAPP) in approximately 1 in 2.7 million doses of OPV. VAPP is caused by a strain of poliovirus that has genetically changed in the intestine from the original attenuated vaccine strain contained in OPV.

2009年5月5日 · Hypogammaglobulinaemic vaccinees can chronically excrete immunodeficient VDPV (iVDPV) for several decades. As long as OPV is used, cVDPV and iVDPV pose a risk of causing poliomyelitis in unprotected individuals and threaten the goal of poliovirus eradication.

vApp (vaccine associated paralytic poliomyelitis)，疫苗相关麻痹型脊髓灰质炎，由于 口服脊髓灰质炎减毒活疫苗 （OPV）使用后毒力回复引起，症状与 脊髓灰质炎 类似。 为避免VAPP的发生临床建议先经两次 IPV 肌注后使用OPV以降低VAPP风险。 [1] vApp (vaccine associated paralytic poliomyelitis)，疫苗相关麻痹型脊髓灰质炎，由于口服脊髓灰质炎减毒活疫苗（OPV）使用后毒力回复引起，症状与脊髓灰质炎类似。

2024年11月27日 · 脊灰疫苗衍生病毒（VDPV）病例，是指该病毒与原始疫苗株病毒相比，VP1区全基因序列的差异介于1%～15%之间（有≥9个碱基发生变异）。 通常为VAPP在人群中持续传播、循环，病毒在机体内复制过程中，基因的变异程序不断加大，神经毒力不断回升，在经过多次人与人之间的循环繁殖后，最终导致其神经毒力与致病性类似或达到野毒株水平，而成为VDPV。 版权说明： 本文版权归原作者所有，转载文章仅为传播更多信息之目的，如作者信息标记有 …