2024年12月25日 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections and Autoimmune Disease, Multisystem, Infantile-Onset, 1 .

Stat3 was first described as a DNA-binding activity from IL-6–stimulated hepatocytes, capable of selectively interacting with an enhancer element in the promoter of acute-phase genes, known as the acute-phase response element (6 – 9).

STAT3 is a transcription fac-tor, a type of protein that regulates when other genes are turned on. Once activated, STAT3 moves into the nucleus of the cell and binds to specific areas of DNA. By binding to regula-tory DNA regions near genes, STAT3 controls the activity of a variety of genes.

STAT3 gene mutations are found in approximately one-third of cases of a blood cancer called large granular lymphocytic leukemia (LGL), which is characterized by the accumulation of white blood cells (lymphocytes) that are abnormally large and contain structures called granules.

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic targets for the treatment of cancer. In particular, STAT-3 serves critical roles in several cellular processes, including the cell cycle, cell proliferation, cellular apoptosis and tumorigenesis.

STAT3 signalling is a major intrinsic pathway for cancer inflammation owing to its frequent activation in malignant cells and key role in regulating many genes crucial for cancer inflammation...

2023年7月5日 · STAT3 is a component of the JAK/STAT pathway that has been claimed to control cell proliferation in cancer and pluripotent stem cells, via their transcriptional and metabolic regulation [12,...

STAT3 is the key regulator of cell proliferation, survival and apoptosis and is constitutively activated in most human cancers, indicating that it can be an important potential therapeutic target for cancer treatment. STAT3 also has important roles in lymphocyte biology, regulation of immune responses and autoimmunity.

2018年12月21日 · Here, we review the tumour-modulating activities of STAT3 in light of its role as a signalling node integrating inflammatory responses during wound healing.

Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as hyperactivation of ...