p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

2025年1月21日 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of …

4 天之前 · PUMA (p53 Upregulated Modulator of Apoptosis) antagonizes anti-apoptotic BCL-2 family proteins, tipping the balance toward cell death. NOXA selectively inhibits MCL-1, a pro-survival protein. The loss of p53 function in cancer often results in defective apoptosis, allowing damaged cells to survive and proliferate uncontrollably.

2024年12月25日 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by …

2023年8月24日 · p53 ensures that cells repair any damaged DNA before cell division by inducing cell cycle arrest to allow time for DNA repair or to force the cell to undergo apoptosis via activation of BAX gene (J Biomed Biotechnol 2011;2011:603925, Cancers (Basel) 2018;10:135)

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

It seems nearly impossible for a normal cell to become a cancer cell unless it inactivates the p53 network. Our current understanding of this network has come from diverse lines of investigation,...

A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body.

2021年12月24日 · Because p53 deficiency is so common in human cancer, this protein is an excellent option for cancer treatment. In this review, we will discuss some of the molecular pathways by which mutant p53 proteins might perform their oncogenic activities, as well as prospective treatment methods based on restoring tumor suppressive p53 functions.

This study identified 350 genes that are confirmed direct p53 targets (see below) based on a meta-analysis of 15 genome-wide datasets and over 300 single-gene studies. These genes have roles in several cellular functions including apoptosis, cell-cycle arrest, autophagy, metabolism, DNA repair, translational control, feedback mechanisms.