Dietary alpha‐ketoglutarate promotes beige adipogenesis and …
DNA methylation is mediated by ten–eleven family proteins (TET) using alpha‐ketoglutarate (AKG) as a cofactor. Here, we demonstrated that the circulatory AKG concentration was reduced in middle‐aged mice (10‐month‐old) compared with young mice (2‐month‐old).
Intracellular α-ketoglutarate maintains the pluripotency of
2014年12月10日 · Direct manipulation of the intracellular αKG/succinate ratio is sufficient to regulate multiple chromatin modifications, including H3K27me3 and ten-eleven translocation (Tet)-dependent DNA...
Alpha-ketoglutarate as a potent regulator for lifespan and …
2023年5月1日 · Alpha-ketoglutarate (AKG) is one of the most important intermediate metabolites in the tricarboxylic acid (TCA) cycle, also known as the Krebs or citric acid cycle, and acts as an essential factor in cellular energy metabolism, amino acid synthesis, collagen synthesis and epigenetic regulation (Harrison and Pierzynowski, 2008).
α-酮戊二酸作为寿命和健康寿命的有效调节剂：证据和观点 - 知乎
AKG 通过抑制 mTOR 和 ATP 合酶 、调节 DNA 和组蛋白去甲基化以及减少 ROS 形成等不同机制发挥作用。 在此，我们总结了 AKG 相关寿命和健康跨度研究的最新发现，并讨论了 AKG 相关的细胞和分子机制，这些机制涉及 延长寿命、改善繁殖以及调节 干细胞 和癌细胞行为。 我们还讨论了 AKG 在延缓衰老和其他潜在应用方面的前景和局限性。 调节 DNA 和组蛋白去甲基化并减少 ROS 的形成。 文章总结了 AKG 相关寿命和健康跨度研究的最新发现，并讨论了 AKG 相关的 …
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene …
2023年4月27日 · The current study is aimed to profile genome-wide DNA (hydroxy)methylation patterns in the hearts of control and streptozotocin (STZ)-induced diabetic rats and decipher the effect of modulation of DNA methylation by alpha-ketoglutarate (AKG), a TET enzyme cofactor, on the progression of DCM.
专家点评丨叶丹团队揭示免疫代谢物衣康酸特异性抑制TET双加氧酶
2022年3月8日 · 发现ITA通过与α-酮戊二酸（α-KG）竞争结合的方式，抑制DNA双加氧酶TET和调控炎症基因表达，并证实TET2是衣康酸抗炎的重要功能靶标。 α-KG被报道与TET2蛋白催化中心H1416、R1896和S1898形成氢键和离子键，并且通过其C-1羧基和C-2酮基与Fe (II)以双齿方式结合 【8】。 与α-KG类似，ITA也是含五个碳原子的二羧酸，尽管拥有C-1位羧基，但其C-2位上的酮基结构被烯烃所替代和无法与Fe (II) 以双齿方式结合，预示着ITA有可能与α-KG竞争结 …
年轻8岁、重返母体……新加坡“抗衰国师” 力推，AKG最新综述！
2023年3月29日 · akg通过调节tet酶（组蛋白去甲基化酶）和dnmt（dna甲基转移酶）辅助去甲基化。 首先，AKG能通过激活TET酶将已分化的细胞重编程为多能干细胞[3]！ 其次，研究发现，干细胞中DNA甲基转移酶3β（ DNMT3B ）的 缺失 会增加 异柠檬酸脱氢酶 （催化AKG生成的酶）的表 …
Mechanisms that regulate the activities of TET proteins - PMC
The ten–eleven translocation (TET) family of dioxygenases consists of three members, TET1, TET2, and TET3. All three TET enzymes have Fe+2 and α-ketoglutarate (α-KG)-dependent dioxygenase activities, catalyzing the 1st step of DNA demethylation by ...
α-Ketoglutarate Accelerates the Initial Differentiation of …
α-ketoglutarate (αKG), a tricarboxylic acid (TCA) cycle metabolite, is a cofactor for αKG-dependent dioxygenase enzymes, which include JmjC-domain containing histone demethylases (JHDMs) and ten-eleven translocation (TET) enzymes (Kaelin and McKnight, 2013). αKG can also bind and block the mitochondrial ATP synthase and inhibit mechanistic ...
α-Ketoglutarate for Preventing and Managing Intestinal Epithelial ...
2024年4月1日 · Potential mechanisms by which α-ketoglutarate (AKG) ameliorates intestinal inflammation through targeting macrophage polarization and T cell differentiation. AKG promotes polarization into anti-inflammatory M2 macrophages through epigenetic modifications and metabolic reprogramming.