易基因｜不同DNA甲基转移酶（DNMT）在癌症发病机制中的作 …
DNA甲基化是指以共价结合方式获得一个甲基（CH3）基团的过程，其是在DNA序列特定碱基的DNMT催化下作为CH3供体的S-腺苷甲硫氨酸（SAM）的化学修饰过程。 在此过程中， 胞嘧 …
Expression and prognosis analysis of DNMT family in acute …
2020年7月7日 · DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia …
Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and …
2019年5月8日 · DNMTs are frequently implicated in the pathogenesis and aggressiveness of acute myeloid leukaemia (AML) patients. In this review, we describe and discuss the …
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA ...
2016年10月10日 · We introduce a mechanism-based strategy to enhance PARPi efficacy based on DNA damage-related binding between DNA methyltransferases (DNMTs) and PARP1. In …
DNMT/G9a Complex Inhibition Uncovers Epigenetic ... - bioRxiv
2024年12月12日 · Here, we demonstrate that AMLs carrying DNMT3A and Nucleophosmin (NPM1) mutations exhibit a specific epigenetic vulnerability toward a complex formed by …
Significance of targeting DNMT3A mutations in AML
2024年7月30日 · This article provides a comprehensive summary and the latest insights into the structure and function of DNMT3A, examines the impact of DNMT3A mutations on the …
DNMTs-mediated SOCS3 methylation promotes the occurrence …
2023年11月11日 · This study aimed to investigate the biological function and mechanism of SOCS3 methylation mediated by DNMTs in the development of AML. Methods: Bone marrow …
DNA Methyltransferase 3B (DNMT3B) Protein Expression
2012年11月16日 · In order to investigate the expression pattern of DNA methyltransferases (DNMTs) in AML patients, we established a tissue microarray (TMA) on bone marrow biopsies …
DNMT3a mutations in high-risk myelodysplastic syndrome parallel …
2011年3月11日 · Our results suggest that DNMT3a mutations may precede the development of AML. MDS is a heterogenous group of clonal bone marrow disorders characterized by …
DNA甲基转移酶基因在MDS患者中的表达及其临床意义
摘要: 研究DNA甲基转移酶（DNA methyltransferase，DNMT）基因在骨髓增生异常综合征（MDS）患者中的表达及其与抑癌基因p15INK4B甲基化状态的相关性，并进一步探讨其与临 …
DNA Methyltransferases: From Evolution to Clinical Applications
In acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), The three DNMTs are overexpressed. DNMT1 and DNMT3A have been described as affected in liver cancer and …
Recurrent DNMT3A mutations in patients with myelodysplastic
2011年3月18日 · DNMT3A mutations have recently been reported in patients with de novo acute myeloid leukemia (AML), providing a rationale for examining the status of DNMT3A in MDS …
The Role of the DNA Methyltransferase Family and the Therapeutic ...
2025年2月5日 · DNMTs facilitate the methylation of cytosines within CpG dinucleotides located in gene promoter regions. They achieve this by transferring methyl groups from the methyl …
DNA methylation of HOX genes and its clinical implications in cancer
2023年12月1日 · In human acute myeloid leukemia (AML), the lncRNA HOTAIR recruits DNMT3B, resulting in hypermethylation of the HOXA5 promoter (Wang et al., 2019). …
DNA Methyltransferase Inhibitors and their Therapeutic Potential
Aberrant DNA methylation at the 5-position of cytosine, catalyzed by DNA methyltransferases (DNMTs), is associated with not only various cancers by silencing of tumor suppressor genes …
DNA methyltransferase-1 in acute myeloid leukaemia: beyond the ...
2022年7月15日 · Shinichi Mizuno et al. analysed DNMTs expression levels of 33 AML cases by competitive PCR and found that DNMT1 was expressed at a high level in most AML cases. …
AML1/ETO cooperates with HIF1α to promote leukemogenesis
2015年3月2日 · A/E and HIF1α shape a positive regulatory loop and cooperate to upregulate DNMT3a expression leading to a DNA hypermethylation profile in AML, which is different from …
Translational Advances in Oncogene and Tumor-Suppressor Gene …
6 天之前 · This process is regulated by DNA methyltransferases (DNMTs), which alter chromatin’s structure to modulate expression . Aberrant DNA methylation is a hallmark of carcinogenesis, …
DNA methyltransferases in hematological malignancies
2020年7月20日 · Accumulating evidence demonstrates that regulation of DNA methylation by DNMTs is critical for normal hematopoiesis. Aberrant DNA methylation due to DNMT …
The BCL2 family: from apoptosis mechanisms to new advances in …
2 天之前 · The epigenetic changes often prime the cells to be more susceptible for additional cytotoxic treatments and may reverse acquired resistance. 166,171,172,173 Most DNMTs …