Abnormal distribution of hDIg and PTEN in premalignant lesions …
2011年6月10日 · Expression levels (positivity/intensity) and localization (nuclear, membrane or cytoplasmic) of PTEN, hDlg and p53 were analyzed by immunohistochemistry in 43 cases with different stages of...
PTEN activation through K163 acetylation by inhibiting HDAC6
2015年8月17日 · In this study, we revealed that non-selective HDAC inhibitors, namely, TSA or suberoylanilide hydroxamic acid (SAHA), induced PTEN membrane translocation through PTEN acetylation at K163 by...
RNA-binding protein PTENα blocks RIG-I activation to prevent …
2024年5月3日 · Here we identify PTENα, an N-terminally extended form of PTEN, as an RNA-binding protein with a preference for the CAUC (G/U)UCAU motif. Using both in vivo and in vitro viral infection assays, we...
Chromatin Regulator, CHD1, Remodels the Immunosuppressive …
In Pten and Pten/Smad4 genetically engineered mouse models, prostate specific deletion of Chd1 resulted in markedly delayed tumor progression and prolonged survival. Chd1 deletion was associated with profound tumor microenvironment remodeling characterized by reduced MDSCs and increased CD8+ T cells.
肿瘤研究热门基因PTEN - 知乎 - 知乎专栏
癌症中PI3K途径效应子的下游激活是PTEN缺失最重要的标志。然而，PTEN缺失也被证明可以通过依赖PIP3的信号激活多种途径，包括 Ras–MAPK 、 Wnt /β-catenin 、 Notch 、 Hippo途径 。 图1. PTEN抑制PI3K途径和AKT的下游致癌信号。
A systematic review of mechanisms of PTEN gene down …
PTEN is a tumor suppressor gene that typically functions to inhibit uncontrolled cellular growth and maintain homeostasis in the PI3K/AKT/mTOR signaling pathway. When PTEN becomes deregulated, its function is compromised, which can contribute to the development of various diseases, including PCa [74,75]. One of the most direct causes of PTEN ...
Hyperphosphorylated PTEN exerts oncogenic properties
2023年5月24日 · PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activity, and protein interactions, but its role in tumorigenesis remains unclear.
PTEN (基因) - 维基百科，自由的百科全书
磷酸酯酶与张力蛋白同源物（英語： Phosphatase and tensin homolog ，简称为PTEN）是一种在人体中由PTEN基因编码的蛋白质 [2] 。 该基因的突变是多种 癌症 进展过程的环节之一。
A pseudogene long noncoding RNA network regulates PTEN …
2016年10月3日 · PTEN is a tumor suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, we characterize a previously unidentified PTENpg1 encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability.
WCLC 2024 | 中国之声：北京大学人民医院研究揭示抑癌基因PTEN …
来自北京大学人民医院的研究团队在WCLC 2024大会发表了一项题为“Restoring Expression of Tumor Suppressor PTEN by Engineered Circular RNA Enhances Osimertinib Sensitivity in Non-Small Cell Lung Cancer”研究，基于对 PTEN 和 PI3K/AKT 通路的理解，研究人员推测恢复 PTEN 的表达可能是奥希替尼耐药 ...