HP1 maintains protein stability of H3K9 methyltransferases and ...
2022年2月15日 · Heterochromatin protein 1 (HP1) governs heterochromatin organization through maintaining protein stability and chromatin binding of H3K9 methyltransferases and …
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3 …
Multiple proteins, including members of the heterochromatin protein 1 (HP1) family, bind H3K9me2/3 and are involved in transcriptional silencing in model organisms. In this work, we …
Reprogramming of H3K9me3-dependent heterochromatin during ... - Nature
2018年4月23日 · Studies in mouse embryonic stem cells (mESCs) have suggested that multiple H3K9me3 modifiers, such as Suv39h1/h2 and ERG-associated protein with SET domain …
Dynamic and flexible H3K9me3 bridging via HP1β dimerization
2016年4月19日 · Here we demonstrate that human HP1β is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. These are caused by dimeric and dynamic …
SETDB1-dependent heterochromatin stimulates alternative
2019年5月8日 · HP1 is relocalized in part at telomeres where it further stimulates SETDB1 recruitment and increases H3K9me3 formation. We found that this excessive heterochromatin …
High-affinity chromodomains engineered for improved detection …
2022年11月15日 · Nanobody-mediated recruitment of endogenous full-length HP1 family members (Cbx1, Cbx3, and Cbx5) to chromatin allowed potent gene silencing, but repression …
Dynamic and flexible H3K9me3 bridging via HP1β dimerization …
2016年4月19日 · We employed genome-wide binding analysis of HP1β in mouse embryonic stem cells (mESC). The sequences of mouse and human HP1β proteins are identical and mESC …
HP1β carries an acidic linker domain and requires H3K9me3 for …
2021年3月4日 · We propose that multivalent interactions of HP1β with H3K9me3-modified nucleosomes via its chromodomain and dimerization via its chromoshadow domain enable …
(PDF) HP1 maintains protein stability of H3K9 ... - ResearchGate
2022年2月15日 · Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to transcriptional suppression and spread of H3K9me2/3. Here, we demonstrate …
Citrullination of HP1γ chromodomain affects association with ... - PubMed
2019年4月2日 · Citrullination is a novel post-translational modification of the structural heterochromatin protein HP1γ in mESCs that is dynamically regulated during mESC …
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