First, we describe the protein nature of the PcG body and the gene silencing factory model. Second, we review the target genes of Polycomb-mediated silencing and discuss their …

2018年1月1日 · Polycomb bodies are foci of polycomb group (PcG) proteins that have been observed within the nucleus of Drosophila and mammalian cells. Their size and number varies …

近日，来自牛津大学的 Neil P. Blackledge 和 Robert J. Klose 在 Nature Reviews Molecular Cell Biology 上发表了题为 The molecular principles of gene regulation by Polycomb repressive …

2012年4月1日 · Polycomb group (PcG) proteins are concentrated in nuclear foci called PcG bodies. Although some of these foci are due to the tendency of PcG binding sites in the …

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized …

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized …

PcG bodies are conspicuous in human osteosarcoma U-2 OS cells where their relative sizes differ from 0.2 to 1.5 μm and their number varies between six and fourteen per nucleus.

2013年8月12日 · A Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly …

2011年5月1日 · Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can …

Polycomb group (PcG) 蛋白是一组通过染色质修饰调控靶基因的转录抑制子, 从生化和功能上它可以分成两个主要的核心蛋白复合体PRC1 (Polycomb repressive complex 1)和PRC2 …