Mannose-6-phosphate pathway: A review on its role in
2012年4月1日 · The explanation of how are the lysosomal enzymes accurately recognized and selected over many other proteins in the trans-Golgi network relies on being tagged with a …
New players and targets in mannose 6-phosphate-dependent lysosomal sorting
2024年11月25日 · These M6P-modified glycans are recognised by mannose 6-phosphate receptors that cycle between the Golgi and endosomes, diverting lysosomal hydrolases from …
信号肽与新生肽链的运输和加工（三） - 知乎专栏
经典的溶酶体定位标签是 甘露糖6-磷酸 （M6P）。 这需要蛋白质中具有特定序列（Asn-X-Ser / Thr），经内质网和高尔基体连续加工修饰产生。 M6P由甘露糖受体（MPR）识别。 MPR有 …
Mannose 6-phosphate receptors: new twists in the tale
2003年3月1日 · The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …
Lysosome sorting of β-glucocerebrosidase by LIMP-2 is ... - Nature
2014年7月14日 · The presence of M6P suggested to us that MPR might attach to LIMP-2 in order to transport β-GCase to the lysosome in a hetero-trimeric complex .
GCAF (TMEM251) regulates lysosome biogenesis by activating the …
2022年9月12日 · Most enzymes utilize the mannose-6-phosphate (M6P) residues as a sorting signal for proper trafficking to the lysosome 1, 2. Because of its importance, the M6P …
Lysosomal enzyme trafficking: from molecular mechanisms to …
2023年7月18日 · The mannose 6-phosphate (M6P)-dependent pathway is the major route for lysosomal enzyme targeting in mammalian cells. Most newly synthesized lysosomal enzymes …
Cation-independent mannose 6-phosphate receptor: From roles …
2024年1月1日 · In this review, we focus on the main roles and functions of the CI-M6PR, its implications in cancer, immunology, brain, and we highlight the studies strengthening the …
Different Pathways to the Lysosome: Sorting out Alternatives
The ligand for the mammalian sorting receptors is mannose 6-phosphate (M6P). Two M6P receptors have been defined in mammals. Here, we review the foundational evidence …
新发现的甘露糖 - 6 - 磷酸依赖蛋白运输途径调节因子，为疾病治疗 …
2025年3月6日 · 为探究甘露糖 - 6 - 磷酸（M6P）依赖的蛋白运输途径，研究人员发现新调节因子，为相关疾病治疗和研究提供方向。 在细胞这个微观世界里，溶酶体就像一个个勤劳的 “清道 …