Recently, functional studies aimed at disrupting AKAP–PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone …

A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信 …

The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of …

AKAPs localize, specify, amplify and accelerate signal transduction within the cell by bringing signaling proteins together in space and time. AKAPs also organize higher-order network …

Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique subcellular targeting …

Arguably the most extensively characterized anchoring protein, AKAP79/150, organizes a veritable mecca of signaling proteins. These include the beta adrenergic receptor (βAR), …

Subcellular compartmentalization of protein kinases and phosphatases through their interaction with A-kinase anchoring proteins (AKAPs) provides a mechanism to control signal transduction …

Dual-specificity protein kinase A anchoring protein 1 (dAKAP1) is a multivalent binding protein that targets protein kinase A (PKA), RNAs, and other signaling enzymes to the outer mitochondrial …

2012年2月1日 · AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of …

Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone …