
Electrophoretic and Cytochemical Characterization of Alpha …
1984年3月1日 · Inhibition studies of cytochemical ANAE activity with sodium fluoride (NaF) show that the presence of NaF-sensitive or NaF-resistant ANAE enzymes is often unrelated to the diagnostic category of acute leukemia.
Electrophoretic and cytochemical characterization of alpha …
Alpha-naphthyl acetate esterases (ANAE) were examined by cytochemical and isoelectric focusing (IEF) techniques in 48 cases of acute myeloid leukemia that were classified by conventional morphological criteria.
收藏贴 | 史上最全急性白血病知识 - 知乎
急性白血病是造血干细胞的克隆性恶性疾病,发病时骨髓中异常的原始细胞(白血病细胞)大量增殖并浸润各种器官、组织,正常造血受抑制。 主要表现为肝脾和淋巴结肿大、贫血、出血及继发感染等。 (1)贫血往往是首起表现,呈进行性发展,主要由于正常RBC生成减少。 (2)发热可低热,亦可高达39~40℃以上,伴有畏寒、出汗等。 较高发热往往提示有继发感染。 感染可发生在各个部位,口腔炎、牙龈炎、咽峡炎最常见,可发生溃疡或坏死;肺部感染、肛周炎、肛旁脓 …
Acute monocytic leukemia diagnosed by flow cytometry includes …
A diagnosis of acute monocytic leukemia (AML-M5) based on α-naphthyl butyrate esterase (α-NB) staining has some problems, because AML-M5 leukemic cells often show weak or faint positivity on α-NB staining. In these situations, some cases of …
Introduction to the diagnosis and classification of monocytic …
Among acute myeloid leukemias (AML), AMML are differentially characterized by the presence of monocytic-lineage maturation features in at least 80% of the blast cells which show appearance of monoblasts, promonocytes, and monocytes.
急性骨髓性白血病 - 维基百科,自由的百科全书
急性骨髓性白血病 (acute myeloid leukemia,AML)又稱 急性髓系白血病 、 急性髓细胞性白血病 (acute myelogenous leukemia),是一组源于髓系 造血干细胞 或 祖细胞 克隆增生形成的恶性肿瘤疾病,克隆性增生可以累及髓系中的一个系列、两个系列或全部系列(红系、髓系和巨核细胞系)。 AML常累及 骨髓 、 外周血 和其他 髓外组织。 在临床、形态学和遗传学上均具有异质性。 AML屬於 骨髓性 血液細胞 過度增生造成的血液 癌症,特色為大量不正常的細胞在 骨髓 和 血 …
从细胞分子学的角度看AML - 知乎
急性髓系白血病 (acute myeloid leukemia,AML),急性髓系白血病是一类异质性血液系统疾病,其发生和发展与造血干细胞的成熟分化障碍、恶性克隆有关。 受累的白血病细胞出现增殖失控、分化障碍、细胞凋亡受阻、骨髓造血功能受损和衰竭。 临床表现为贫血、出血、感染及由白血病细胞浸润引起的肝、脾和淋巴结肿大等症状。 世界卫生组织国际癌症研究机构(IARC)发布了2020年全球最新癌症死亡数据. 1.2 FAB分类. 主要依靠细胞化学染色和骨髓细胞形态学 (骨髓 …
Acute Leukemia Cytochemical Profile: Diagnostic and Clinical ...
A Wright stain, peroxidase, PAS, NASDA, and NASDA-F were performed on each case. The cytochemical diagnosis was correlated with the investigator’s morphological diagnosis. Sixteen ECOG cases were classified as myeloblastic (AML), 10 as myelomonocytic (AMML), and 4 as monocytic (AMoL). Two cases were reclassified as ALL.
Acute myelomonocytic leukemia - Wikipedia
Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts. AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow.
神刊发表综述,阐述AML的治疗和研究新进展-MedSci.cn
2024年12月13日 · 影响因子503分的神刊《CA-A Cancer Journal for Clinicians》是美国癌症协会的旗舰期刊,近日发表综述“Acute myeloid leukemia management and research in 2025”,通讯作者为MD安德森癌症中心Hagop M. Kantarjian教授,作者回顾了AML的一线和后线疗法,并讨论了重要的研究方向。 引言. 在过去的50年中,AML的治疗主要是一种中度有效但耐受性较差的标准治疗:阿糖胞苷和联合蒽环类,通常称为7+3方案(或3+7或3+10),包括7-10天阿糖胞苷和3 …