2019年3月18日 · Computations in the medial prefrontal cortex (mPFC) are thought to be central to cognitive operation, including decision-making and memory. We used a retrograde trans-synaptic rabies...

2007年12月5日 · Using different versions of the Morris water maze, we explored the roles of the CA3 subregion of the hippocampus and the medial prefrontal cortex (mPFC) in spatial memory retrieval under various conditions. In a hidden platform task, both CA3 and mPFC lesions disrupted memory retrieval under partial-cue, but not under full-cue, conditions.

2024年2月22日 · 所有神经元（每个垂直线一个）在 7 个 HIP 亚区（DG，CA3，CA2，CA1，SUB，ProS，SUBr）中按其胞体位置沿 D-V 轴排序，下方显示神经元数目。 下游目标分为 9 个主要区域，即同侧和对侧 HPF，ISO，OLF，CTXsp，CNU，TH，HY，MB，显示在左侧（请参见 table S3 中所有缩写的全名）。 投射强度由目标区域中的总轴突长度（以微米为单位）定义，并进行颜色编码（下方 …

2024年9月2日 · Here, we showed that neuronal activity in the dHP affects stress-coping behaviors in mice via excitatory projections to the medial prefrontal cortex (mPFC). The antidepressant ketamine rapidly...

The interplay between medial prefrontal cortex (mPFC) and hippocampus, particularly the hippocampal CA3 area, is critical for episodic memory. To what extent the mPFC also interacts with the hippocampus CA1 subregion still requires elucidation. To investigate this issue, male rats received unilatera …

Functional magnetic resonance imaging (fMRI) was used to identify brain- wide networks that are activated by electrical stimulation of either the ventral tegmental area (VTA) or hippocampal CA3 region.

2021年12月20日 · This study reveals extensive non-canonical synaptic inputs to dorsal hippocampal CA3 from ventral CA1, perirhinal cortex and subicular complex, and shows that genetic inactivation of projection from ventral CA1 to dorsal CA3 impairs object-related spatial learning and memory.

2024年7月1日 · Here, using an incidental memory recognition task in rats, we showed that retrieval of a contextually guided memory is reflected by the levels of CA3 remapping, demonstrating a clear link between external cues, hippocampal remapping, and episodic memory retrieval that guides behavior.

We asked whether episodic-like memory requires neural mechanisms independent of those that mediate its component memories for "what," "when," and "where," and if neuronal connectivity between the medial prefrontal cortex (mPFC) and the hippocampus (HPC) CA3 subregion is essential for episodic-like m …

功能磁共振成像（fmri）用于鉴定通过腹侧被盖区（vta）或海马ca3区的电刺激而激活的全脑网络。 刺激这些区域之一会在常见结构（例如隔垫和左右海马区）中以及在独特结构（例如内侧前额叶皮层区域/前扣带区域（mPFC / ACC）和纹状体）中引起明显的BOLD反应 ...