2020年9月14日 · Our study identified the number of CD2 molecules per cell as controlling its location in the IS and co-stimulatory efficiency. These findings provided a framework to interpret the significance of...

2023年10月5日 · To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic “universal” CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to prevent...

2024年11月5日 · We assessed the impact of CD2:CD58 axis disruption in CAR T cells and developed a strategy to compensate for the lack of CD58 costimulation. Methods and Results: We deleted CD2 in anti-CD19 CAR T cells (CD2KO CART19) using CRISPR-Cas9 and demonstrated reduced in vitro cytotoxicity compared to CD2 wild-type CART19 (CD2WT CART19) using a B …

2024年2月17日 · CD2蛋白是一种跨膜糖蛋白，是最早的T细胞标记物之一，广泛表达于人类T细胞、自然杀伤细胞（NK细胞）、部分B细胞和单核细胞等免疫细胞表面。 它参与T细胞激活的共刺激途径，在免疫细胞间的相互作用和信号传导中扮演着重要角色。 （数据来源 Ho P, et al. Cancer Cell. 2023） CD2结构： CD2由327个氨基酸 (包括信号序列)和组成，约40kd，全糖化CD2的可达50kd，CD2的细胞外域 (ECD，25-209)由两个Ig样结构域组成，并通过跨膜螺旋与富含脯氨酸 …

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, [ 5 ] LFA-3 receptor, erythrocyte receptor and rosette receptor.

2024年11月5日 · CD2 is a costimulatory receptor on T-cells, present in the immune synapse and important for T-cell activation and adhesion to antigen-presenting cells. We report here findings of a novel CD19-directed CAR design incorporating a secreted trispecific immune effector cell engager (TRIEC) consisting of three single chain variable fragments (scfv ...

根据该命名系统，已经充分表征的抗原将会分配数字（例如，cd1、cd2 等），而对于仅有一种单克隆抗体可以识别的抗原分子，则分配临时名称“cdw”。在生理学上，cd 抗原不属于任何特定的分子种类，它们具有从细胞表面受体到粘附分子的多种功能。

cd2又称淋巴细胞功能相关抗原2（ifa-2）或绵羊红细胞（srbc）受体，为跨膜单链分子，表达于t细胞、胸腺和nk细胞。人cd2分子的配体是cd58（lfa-3）。cd2与cd58结合，能增强t细胞与apc或靶细胞间粘附，促进t细胞对抗原识别和cd2所介导的信号转导。

2010年12月15日 · This research investigates the long-term kinetics of Cd (2+) sorption and desorption by calcium-exchanged clinoptilolite (CaCpt) and Y-type (CaY) zeolite using isotopic exchange with (109)Cd while maintaining pH at circumneutral values.

The CD2-CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse (IS), with cellular or artificial APC, in a pattern we refer ...