无义介导的mRNA降解（nonsense-mediated mRNA decay, NMD）是真核细胞中监控RNA的重要机制，它可以识别并降解开放阅读框中含有 提前终止密码子 (premature termination codon, PTC)的mRNA，以避免因截短的蛋白产物积累对细胞造成毒害。

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无义介导的mRNA降解 （英語： Nonsense-mediated mRNA Decay，常简写为 NMD机制 或 NMD）是一种存在于所有 真核生物 中的 遗传纠错机制 （英语：MRNA surveillance）。 这一机制透过降解含有提前 终止密码子 的异常 mRNA 转录子以减少基因表达上的错误。 [1] 如果没有这一机制，这些异常的mRNA可能会翻译出有害的功能获得性或 具有显性抑制效应 （英语：Dominant negative mutation） 的蛋白质，可能损害人体正常的生理机制。 [2] NMD机制在1979年几乎同 …

2016年6月2日 · Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease.

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2021年8月13日 · To identify and analyze endogenous targets of NMD, we apply cDNA Nanopore sequencing and short-read sequencing to human cells with varying expression levels of NMD factors. Our approach detects full-length NMD substrates that are highly unstable and increase in levels or even only appear when NMD is inhibited.

2021年7月1日 · Genomic analyses have quantified the importance of known and novel 'rules of nonsense-mediated mRNA decay (NMD)', allowing accurate prediction of whether premature termination codon (PTC)-containing mRNAs are degraded or not.

2022年3月1日 · Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating embryonic stem cell (ESC) differentiation, but the exact mechanism is unclear. Here we show that NMD controls expression levels of the translation initiation factor Eif4a2 and its premature termination codon-encoding isoform (Eif4a2PTC ).

2022年9月17日 · In this study, we set out to establish Nanopore direct RNA sequencing in combination with quantitative real-time PCR (qPCR) as a method for analyzing NMD activity and its targets in cultured cell lines and clinical tissue samples.

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