[68Ga]/[90Y]FAPI-46: Automated production and ... - ScienceDirect
2022年7月1日 · Trisodium citrate 1 M solution (pH 5) was applied as eluent to determine free [68 Ga]Ga 3+ ions at Rf ≥0.8 and [68 Ga]Ga-FAPI-46 at Rf ≥ 0.2 (Fig. 6 d). Both TLC methods …
Fully-automated synthesis of 177Lu labelled FAPI derivatives on …
2021年4月16日 · A fully automated synthesis of [177Lu]Lu-FAPI derivatives was achieved on the Modular Lab Eazy (ML Eazy) with high radiochemical yield ([177Lu]Lu-FAPI-04; 88% ± 3, …
Automated synthesis of [68Ga]Ga-FAPI-46 without pre …
2022年7月29日 · The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical advantages. …
Radiochemical synthesis and pre-clinical evaluation of [68Ga]Ga-FAPI …
2024年5月13日 · The present work describes the formulation of a lyophilized Fibroblast Activation Protein Inhibitor-4 (FAPI-4) kit for preparation of [68Ga]Ga-FAPI-4 in high radiochemical yield …
FAPI成像分析：突破传统PET/CT在癌症诊断中的局限性 - 知乎
基于 FAPα抑制剂（FAPI）的 PET/CT显像因受血糖影响小、肿瘤摄取迅速及较高的肿瘤/背景比值（TBRs）等特点，在临床中显示出良好的应用前景。 本综述旨在详细探讨FAPI成像技术的分 …
Automated Synthesis of [68Ga]Ga-FAPI-46 on a Scintomics GRP
2023年8月11日 · [68Ga]Ga-FAPI-46 is a radiolabelled fibroblast activation protein inhibitor that selectively binds to fibroblast activation protein (FAP), which is overexpressed by cancer …
Fully-automated production of [68Ga]Ga-FAPI-46 for clinical …
2020年12月17日 · [68 Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of …
From fully automatized synthesis of [68Ga]Ga-DATA5m-FAPi to …
2022年8月1日 · In this study we performed automated synthesis of [68Ga]Ga-DATA.SA.FAPi, a FAPi linked to the hybrid chelator DATA5m via a squaric acid as well as the first use of 68Ga …
一种放射性核素标记FAPI的化合物及其合成工艺方法与流程
近年来，基于喹啉设计的小分子fap抑制剂(fapinhibitor，fapi)显示出优秀的fap亲和力，多种68ga-fapi也在动物实验中显示了高度的肿瘤摄取和快速的体内清除，非常适用于体内成像，目前国 …
FAPI-46 | FAP示踪剂 | MCE - MCE-生物活性分子大师
FAPI-46 是一种喹啉类成纤维细胞活化蛋白 (FAP) 靶向示踪剂。 使用放射性 68 Ga 或 177 Lu 标记的 FAPI-46 可用于多种癌症的肿瘤成像，具有更高的肿瘤摄取率和更长的肿瘤蓄积时间。 * …